Patients received 8 weekly infusions of nimotuzumab. The first nimotuzumab infusion was administered 1 week before starting radiation, whereas the remaining doses were administered concomitantly with irradiation. Paired biopsies www.selleckchem.com/products/p5091-p005091.html were taken from skin and primary tumors, before (pretherapy) and 1 week (on single-agent therapy) after first infusion. Immunohistochemistry was conducted to assay the effects of nimotuzumab on total and phosphorylated

EGFR, phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2), p-AKT, and proliferation (Ki-67).\n\nResults: Nimotuzumab was well tolerated and there was no evidence of skin rash. Objective response was achieved in Selleck AS1842856 9 of 10 patients. The pharmacodynamic assays showed inhibition of p-EGFR in both skin and tumor (P = 0.042 in skin and P = 0.034 in tumor). No significant changes in p-ERK1/2, p-AKT, or Ki-67 were detected in skin. In addition, lymphocytic infiltrates, folliculitis, or perifolliculitis were not observed. In tumor samples, there was an upregulation of p-AKT (P = 0.043), a reduction

in proliferation index (P = 0.012), and a nonsignificant trend toward a decrease of p-ERK1/2 (P = 0.091).\n\nConclusions: The pharmacodynamic data confirmed the ability of nimotuzumab to decrease EGFR phosphorylation. Downstream effects were observed in tumor cells but not in skin, a finding that may help to explain the lack of skin rash in patients treated with nimotuzumab. Clin Cancer Res; 16(8); 2474-82. (C) 2010 AACR.”
“Our learn more previous study showed that hypermethylation of dimethylarginine dimethylaminohydrolase

2 contributes to homocysteine-induced apoptosis of human umbilical vein endothelial cells. Epigallocatechin-3-gallate is a green tea-derived phenol which has been proved beneficial on atherosclerosis. It was demonstrated that epigallocatechin-3-gallate inhibits DNA methyltransferase activity and 3 reactivates methylation-silenced genes in cancer cells. The aim of this study was to address whether epigallocatechin-3-gallate could induce DNA demethylation of the dimethylarginine dimethylaminohydrolase 2 gene, contributing to prevent endothelial cells from apoptosis induced by homocysteine. Human umbilical vein endothelial cells (ATCC, CRL-2480) were treated with homocysteine (1mM) for 48 hours with or without epigallocatechin-3-gallate (20 mu M) or 5Aza (DNA methyltransferase inhibitor, 5 mu M). Apoptosis rate of human umbilical vein endothelial cells was assayed by flow cytometry with an annexin V-FITC apoptosis detection kit. The mRNA and protein expression level of dimethylarginine dimethylaminohydrolase 2 and DNA methyltransferase 1 were detected by real-time PCR and Western blot, respectively. DNA methylation level of dimethylarginine dimethylaminohydrolase 2 was assayed by methylation specific PCR.

In conclusion, this ELISPOT assay could provide Nepicastat cost useful support in diagnosing LTBI in hepatitis C patients and may provide guidance regarding the treatment of LTBI and hepatitis C co-infection.”
“Aims: The developmental origins of health and disease hypothesis states that later-life disease may be influenced by the quality of the in utero environment. Environmental

toxicants can have detrimental effects on fetal development, potentially through effects on placental development and function. 432 Maternal smoking during pregnancy is associated with low birth weight, preterm birth and other complications, and exposure to cigarette smoke in utero has been linked to gross pathologic and molecular changes to the placenta, including differential DNA methylation in placental tissue. The aim of this study was to investigate the relationship between maternal smoking during pregnancy, methylation changes in the placenta and gestational age. Materials & methods: We used Illumina((R))’s NVP-LDE225 (CA, USA) Human Methylation27 BeadChip

technology platform to investigate the methylation status of 21,551 autosomal, non-SNP-associated CpG loci in DNA extracted from 206 human placentas and examined loci whose variation in methylation was associated with maternal smoking during pregnancy. Results: We found that methylation patterns of a number of loci within the RUNX3 gene were significantly associated with smoking during pregnancy, and one of these loci was associated with decreased gestational age (p = 0.04). Conclusion: Our findings, demonstrating maternal smoking-induced changes in DNA methylation at specific loci, suggest a mechanism by which in utero tobacco smoke exposure could exert its detrimental effects upon the health selleck chemicals of the fetus.”
“PURPOSE. To evaluate the results of phacoemulsification and intraocular lens implantation after deep anterior lamellar keratoplasiy (DALK).\n\nMETHODS. Retrospective, consecutive, noncomparative, single-surgeon series.\n\nRESULTS. Sixteen eyes of 16 patients were included (mean age: 51 years). Five eyes

had phacoemulsification because of cataract, and 11 eyes for myopic refractive lens exchange. No intraoperative or postoperative complications were noted. Mean spherical equivalent (SE) improved from -8.69 D (SD 3.74) to -0.97 D (SD 1.13). Mean preoperative defocus equivalent (DE) improved from 10.32 D (SD 4.04) to 2.57 D (SD 0.92). Mean preoperative best spectacle-corrected visual acuity improved from 0.48 logMAR (SD 0.60) to 0.13 D (SD 0.005). Mean postoperative uncorrected visual acuity was 0.675 logMAR (SD 0.252). Safety index was 2.33, efficacy index was 0.70, and endothelial cell loss was not significant.\n\nCONCLUSIONS. Phacoemulsification can provide safe and predictable visual rehabilitation for cataract and refractive errors resulting after DALK.

There were 48% who had findings considered disqualifying according to JAR FCL-3. Three cases (14%) showed thin cap fibroatheromas (TCFA). There were 15 ergometry tests recorded prior to the accident that could be reviewed. Minor findings were more frequent in the groups of more severe CAD, but not statistically significant. Laboratory findings did not correlate with CAD severity. Only serum cholesterol levels in the “disqualifying” group of the JAR-FCL classification were slightly higher compared to the remaining cases. Discussion: Our results suggest

that ergometry findings may help to identify individuals with asymptomatic CAD. Further verification, e.g., by noninvasive selleckchem coronary imaging, would then be the basis for strict cardiovascular risk management. For future aeropathological

studies on the prevalence of CAD, we suggest that a classification system be established regarding higher degree luminal narrowing as well as plaque morphology, and especially the occurrence of TCFA.”
“Aims: To evaluate glycaemic control and usability of a workflow-integrated algorithm for basal-bolus insulin therapy in a proof-of-concept SBE-β-CD study to develop a 123 decision support system in hospitalized patients with type 2 diabetes. Methods: In this ward-controlled study, 74 type 2 diabetes patients (24 female, age 68 +/- 11 years, HbA1c 8.7 +/- 2.4% and body mass index 30 +/- 7) were assigned to either algorithm-based treatment with a basal-bolus insulin therapy or to standard glycaemic management. Algorithm performance was assessed by continuous glucose monitoring and staff’s adherence to algorithm-calculated insulin dose. Results: Average blood glucose levels (mmol/l) in the algorithm group were significantly reduced from 11.3 +/- 3.6 (baseline) to 8.2 +/- 1.8 (last 24 h) over a period of 7.5 +/- 4.6 days (p smaller than 0.001). The algorithm HSP990 molecular weight group had a significantly higher percentage of glucose levels in the ranges from 5.6 to 7.8 mmol/l (target range) and 3.9 to 10.0 mmol/l compared with the standard group (33 vs. 23%

and 73 vs. 53%, both p smaller than 0.001). Physicians’ adherence to the algorithm-calculated total daily insulin dose was 95% and nurses’ adherence to inject the algorithm-calculated basal and bolus insulin doses was high (98 and 93%, respectively). In the algorithm group, significantly more glucose values smaller than 3.9 mmol/l were detected in the afternoon relative to other times (p smaller than 0.05), a finding mainly related to pronounced morning glucose excursions and requirements for corrective bolus insulin at lunch. Conclusions: The workflow-integrated algorithm for basal-bolus therapy was effective in establishing glycaemic control and was well accepted by medical staff. Our findings support the implementation of the algorithm in an electronic decision support system.”
“Melanoma is the fatal form of skin cancer.

A 432 control group (n = 47) consisted of age-and body mass index (BMI)-matched healthy subjects Ricolinostat supplier with a normal OGTT. Circulating concentrations of lipids, insulin, interleukin-6 (IL-6), interleukin-8 (IL-8) and high sensitive C-reactive protein (hsCRP) were measured. HOMA index was calculated. Results. Subclinical inflammation markers were elevated in patients with diabetes and IFG/IGT compared to healthy

controls and also IFG patients (diabetes vs. control: p < 0.05 for hsCRP, IL-8, and IL-6; IFG/IGT vs. control: p < 0.05 for hsCRP, and IL-6; diabetes vs. IFG: p < 0.05 for hsCRP, and IL-6; IFG/IGT vs. IFG: p < 0.05 for hsCRP, and IL-6). In multiple

regression analysis, postload glucose concentration was independently associated with circulating hsCRP and IL-6 concentrations when the data was controlled for age, gender, BMI and lipid concentrations (p < 0.05 for hsCRP, and IL-6). Conclusion. Our results suggest that patients with prediabetes, independent of underlying obesity, have increased concentrations of subclinical inflammation www.selleckchem.com/products/BI6727-Volasertib.html which is mostly driven by postload glucose concentrations.”
“Several studies in schizophrenia found a positive association between cognitive performance and work status, and it has been reported that good cognitive performance at the outset does predict the success of vocational interventions. However little has been done to investigate whether vocational interventions itself benefit cognitive performance. To test this hypothesis we performed a randomized, placebo-controlled trial to investigate in remitted schizophrenic patients the effect of a 6-months vocational rehabilitation program on cognitive performance. We recruited 112 remitted and clinically stable schizophrenic patients

who aimed to enter a vocational rehabilitation program. From these, 57 immediately entered H 89 a 6-months vocational rehabilitation program, whereas the remaining 55 were allocated to a waiting-list; the latter formed our control group, which received during the 6 months out-clinic follow-up treatment. Before and after the 6-months period we assessed changes in cognitive performance through a neuropsychological test battery, as well as changes in the psychopathological status and in quality of life. We found that vocational rehabilitation significantly improved patients’ performance in cognitive measures that assess executive functions (concept formation, shifting ability, flexibility, inhibitory control, and judgment and critics abilities). Moreover, after 6 months the vocational group improved significantly in the negative symptoms and in quality of life, as compared to controls.

However, the literature regarding prevention strategies and the presentation of spinal metastases has remained scarce. As local control of primary lesions continues to improve, more cases of spinal metastases are likely to be seen. In this review the authors present a new case of metastatic

GBM to the L-5 nerve root, and they summarize previous cases of intracranial GBM with leptomeningeal spinal metastatic disease. They also characterize key features of this disease presentation and discuss areas of future investigation necessary for enhanced prevention and treatment of this complication. (http://thejns.org/doi/abs/10.3171/2012.7.SPINE12212)”
“A new pentacyclic oleanene triterpene, 2, 3, 16, 28-tetrahydroxy-olean-12-ene-23-oic

acid (1), as well as the known pentacyclic triterpene medicagenic acid (2), have been isolated by different chromatographic C59 Wnt techniques from the acid hydrolysate of the saponin fraction of Gladiolus segetum. The identification A-1155463 ic50 of these compounds was established by different methods of physical, chemical and spectral evidence.”
“Barberry (Berberis spp.) hosts the aecial stage of several rust species, including Puccinia graminis, which causes stem rust on grasses and cereals. The aecial stage of this pathogen has received less attention because it is not as economically important compared with the uredinial and telial stages. The main objective of this study was to identify and describe the rust species

that were found on Berberis spp. collected Stem Cell Compound Library in different parts of Sweden. A morphological study, including spore measurements and aecia descriptions, was conducted, as well as DNA sequence analyses (using the internal transcribed spacer region and the EF1-alpha gene). Based on spore and aecia morphology as well as the genetic analyses, three different taxa could be distinguished on barberry: P graminis f. sp. avenae, P graminis f. sp. tritci/secalis, and P. arrhenatheri. The genetic analysis revealed little or no differentiation between P graminis f. sp. tritici and P graminis f. sp. secalis and, thus, this group of samples was denominated P graminis f. sp. tritici/secalis. Aecial morphology may be used to differentiate between different taxa. In particular, examination of aecial cross-sections may be used to distinguish between P graminis f. sp. avenae and P graminis f. sp. triticilsecalis. A clear differentiation in the mode of growth on barberry was also found; P arrhenatheri always appeared systemic whereas P graminis always appeared localized.”
“In this article, intellectual property (IP), its various types and the rights of patentee are defined. Challenges for Indian IP professionals at academia and IP firms are also identified.

In addition, fast-scan cyclic voltammetry revealed that bHRs had more spontaneous dopamine ‘release events’ in the core of the nucleus accumbens than bLRs. Thus, bHRs exhibit parallels to ‘externalizing disorders’ in humans, representing a genetic animal model of addiction vulnerability associated JIB-04 ic75 with a propensity to attribute incentive salience to reward-related cues, behavioral disinhibition, and increased

dopaminergic ‘tone.’ Neuropsychopharmacology (2010) 35, 388-400; doi: 10.1038/npp.2009.142; published online 30 September 2009″
“Introduction. – Neurological manifestations of celiac disease are rare and polymorphic. Similar to lesions of the digestive tract, the standard treatment includes steroids.\n\nCase report. – A 41-year-old woman, followed up for celiac disease resistant to gluten-free diet, developed rapidly spastic paraparesis, cerebellar syndrome, horizontal diplopia and decline of visual acuity. The diagnosis of neurological complications of celiac disease

was established and the patient was treated with methylprednisolone, followed by oral prednisone. For 9 years, the patient’s neurological status remained stabilized with a prednisone dose at 20 mg per selleck chemicals day. The patient relapsed when progressive reduction of prednisone dose was attempted; neurological and gastrointestinal signs worsening at 15 mg per day; increasing the dose to 30 mg improved the clinical status.\n\nDiscussion. – The mechanism of onset of neurological disease remains unknown. Immunological, nutritional, toxic or metabolic factors could be involved. The positive response to corticosteroids observed in this patient suggest an immunological mechanism. (C) 2009 Elsevier Masson SAS. All rights reserved.”
“BACKGROUND: The Blalock-Taussig shunt (BTS) was introduced 68 years ago before open repair of cyanotic congenital heart disease (CHD) was possible. The originally described technique has undergone many modifications but remains an integral component Dinaciclib cell line of the management of cyanotic CHD. We report our contemporary,

single institution experience with the BTS.\n\nSTUDY DESIGN: We performed a retrospective review of all patients treated with a BTS from June 1995 to December 2011.\n\nRESULTS: There were 730 BTS performed in 712 patients; 727 (99.6%) by interposition graft (modified). The BTS was predominantly right-sided (n = 657, 90%). Median age and weight at palliation were 8 days (range 0 days to 18.5 years) and 3.2 kg (1.5 to 51 kg). Median hospital length of stay was 16 days (range 0 to 347 days). There were 241 (33%) BTS performed as initial palliation for ultimate 2-ventricle (2V) circulation, 471 (65%) as part of staged palliation for patients with functionally univentricular lesions (1V), 6 (1%) as a part of 1.5-ventricle palliation, and 12 (1%) for Ebstein’s anomaly.

In this group, six patients had >= 20% drop in rSO(2), and >= 50% drop in FVm. However, two patients had a non-significant drop in both rSO(2) and FVm (false negative). In the non-shunted group (41/49), one patient had a significant drop in rSO(2) (false

positive) while 10/41 patients had a >50% drop in FVm. This represents sensitivity of 75%, and specificity of 97.5% for CO compared to sensitivity of 75% and specificity of 75% for TCD in prediction of shunting. The positive predictive value and negative predictive value were 85.7 and 95.2%, respectively for CO, compared to 37.5 and 93.9% for TCD. Conclusions: TCD is less accurate than CO in predicting the need for carotid shunting during CEA. A combination of both methods does not add to the accuracy of detecting the need for carotid Navitoclax shunting. (C) 2011 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.”
“The delivery of site-specific post-translational modifications to histones generates an epigenetic regulatory network that directs fundamental DNA-mediated processes and governs key stages in development. Methylation

of histone H4 lysine-20 has been implicated in DNA repair, transcriptional GW786034 silencing, genomic stability and regulation of replication. We present the structure of the histone H4K20 methyltransferase Suv4-20h2 in complex with its histone H4 peptide substrate and S-adenosyl methionine cofactor. Analysis of the structure reveals that the Suv4-20h2 active site diverges from the canonical SET domain configuration and generates

a high degree of both substrate and product specificity. Together with supporting biochemical data comparing Suv4-20h1 and Suv4-20h2, we demonstrate that the Suv4-20 family enzymes take a previously mono-methylated H4K20 substrate and generate an exclusively di-methylated product. We therefore predict that other enzymes are responsible for the tri-methylation of histone H4K20 that marks silenced heterochromatin.”
“Objective: Visuospatial working memory impairments have been implicated in the pathophysiology of LY3023414 4 attention-deficit/hyperactivity disorder (ADHD). However, most ADHD research has focused on the neural correlates of nonspatial mnemonic processes. This study examined brain activation and functional connectivity for visuospatial working memory in youth with and without ADHD. Method: Twenty-four youth with ADHD and 21 age- and sex-matched healthy controls were scanned with functional magnetic resonance imaging while performing an N-back test of working memory for spatial position. Block-design analyses contrasted activation and functional connectivity separately for high (2-back) and low (1-back) working memory load conditions versus the control condition (0-back). The effect of working memory load was modeled with linear contrasts.

Between 2006 and

2008, varenicline use rates increased from 0.4% to 21.7% in the US, 0.0% to 14.8% in Canada, 0.0% to 14.5% in Australia, and 0.0% to 4.4% in the UK. In contrast, use of NRT and bupropion remained constant in each country. Males and non-whites were significantly less likely to report using any SSM, while more educated smokers were significantly more likely to use any SSM, including varenicline. Our findings suggest that the introduction of varenicline led to an increase in the number of smokers who used evidence-based treatment during their quit attempts, rather than simply gaining market share at the expense of other medications. From a public health perspective, messages regarding increased success rates among medication users and the relative safety of stop smoking medications should be disseminated widely so as to reach all smokers of all socioeconomic classifications equally.”
“We NVP-LDE225 investigated the role of intermolecular interactions as a thermodynamic driver of phase transition behavior in polymer solutions. Molecular simulations based on a Monte-Carlo sampling technique were used to directly evaluate the intermolecular energy between specific molecules. The thermal energy behavior of several polymer solutions was determined from

the simulation results. The degree of miscibility and types of liquid liquid equilibrium (LLE), including upper critical solution BGJ398 molecular weight temperature (UCST) and lower critical

solution temperature (LCST) phase transition behavior, were studied qualitatively. A quantitative description based on a thermodynamic model was also applied to generate temperature composition GSI-IX phase diagrams, and the simulated energy values were directly incorporated into the model. A modified double lattice (MDL) model with chain 123 length dependence was adopted as a reference thermodynamic framework, and the calculated coexistence curves were fairly close to the phase transition boundary of reported experiments. The proposed modeling technique can serve as a screening tool that enables the development of stable formulations. (C) 2012 Elsevier Ltd. All rights reserved.”
“Objective: The aim of this study was to examine the abbreviated Desires for Alcohol Questionnaire (DAQ) with respect to component structure and concurrent validity. Method: The DAQ was administered to 2,960 adults participating in the Collaborative Studies on the Genetics of Alcohol. Rotated principal components analysis was conducted on 1,500 subjects with an alcohol-use disorder (AUD) and on 1,460 non-AUD subjects. Total DAQ scores were compared for these two subsamples. In addition, correlations were computed between DAQ scores and the following: (1) a sum of alcohol symptoms, and (2) endorsement of a single interview craving question.

Advanced fibrosis (F3 or F4) could be efficiently CDK and cancer predicted by a FibroScan cut-off value of 15 kPa.

The FibroScan sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 100%, 73.9%, 77.8%, 100%, and 86.4%, respectively.\n\nFibroScan values gave a good correlation with various markers of fibrosis and increased proportionally with the progression of the hepatic fibrosis stage. A FibroScan value of 15 kPa was found to be a significant separation limit for differentiating advanced fibrosis stages (F3 and F4) from the milder stages (F0-F2). FibroScan values are clinically useful for predicting the fibrosis stages and helpful in managing interferon therapy in patients with chronic hepatitis C.”
“Laryngeal radionecrosis is one of the most troublesome late complications of radiotherapy, because it is frequently resistant to treatment and laryngectomy is required in the worst case. Here, we selleck report a case of laryngeal radionecrosis, successfully treated by use of hyperbaric oxygen (HBO) therapy, in which laryngectomy was avoided. A 67-year-old male received radical chemoradiotherapy (CRT) for mesopharyngeal cancer, which included radiotherapy with a total

dose of 71.4 Gy/38 Fr and chemotherapy with CDDP + S-1. He developed dyspnea and throat pain 9 months after completion of CRT. Laryngoscopy revealed vocal cord impairment because of severe laryngeal edema. He was diagnosed as having laryngeal radionecrosis and initially received

conservative therapy combined with antibiotics, steroids, and prostaglandins. Because his dyspnea was persistent despite this treatment, HBO therapy was administered 20 times, and resulted in complete remission of the dyspnea. HBO therapy, therefore, is regarded as an effective conservative therapeutic option for laryngeal radionecrosis.”
“A new diamine containing a bulky diphenylquinoxalin pendant, 3,5-diamino-N-(2,3 3-diphenylquinoxalin-7-yl)benzamide (DQB), was synthesized find more in four steps through the nucleophilic aromatic substitution of 3,5-dinitrobenzoylchloride with 2,3-diphenylquinoxalin-6-amine and subsequent catalytic reduction. All intermediates and DQB were fully characterized by FTIR, NMR and elemental analysis. A series of polyamides PA(a-e) was synthesized from this diamine by direct polycondensation with various dicarboxylic acids, triphenyl phosphate and pyridine in N-methyl-2-pyrrolidynone (NMP). Three polyimides PI(a-c) were synthesized from this diamine using commercial dianhydrides in two-step polycondensation. Characterization of polymers was accomplished by FTIR, H NMR, elemental analysis, DSC, DMTA, GPC, and TGA. The intrinsic viscosities of PAs ranged from 0.54 to 0.67 dL/g. PAs displayed T (g) values of 140-298 degrees C and 10% weight loss of 415-485 degrees C in N(2).

The associations of human chromosomes HSA1/19 and 5/21 were found to be chromosome signatures for the group and provided further support for Afrotheria. Additional chromosome synapomorphies were also identified linking elephants and manatees in Tethytheria (the associations HSA2/3, 3/13, 8/22, 18/19 and the lack of HSA4/8) and elephant shrews with the aardvark (HSA2/8, 3/20 and 10/17). Herein, we review the current knowledge on Afrotheria chromosomes and genome evolution. The already available data on the group suggests that further work on this apparently bizarre assemblage of mammals will provide important data to a better SCH 900776 understanding on mammalian genome evolution.

Copyright (C) 2012 S. Karger AG, Basel”
“Perinatal exposure to environmental levels of bisphenol-A (BPA) impairs sexually dimorphic behaviors in rodents. Kisspeptin neurons in anteroventral periventricular nucleus (AVPV), which plays an important role in the activation of GnRH neurons and the initiation of LH-surge, have been suggested to be sexual dimorphism in rats. This study focused on exploring the 3 influence of a perinatal exposure to an environmental dose of BPA on the development and maturation of male AVPV kisspeptin neurons and hypothalamus-pituitary-gonadal Natural Product Library in vivo axis. Female rats were injected sc with 2 mu g BPA/kg.d from gestation

d 10 through lactation d 7. Anatomical and functional changes in AVPV kisspeptin neurons and hypothalamus-pituitary-gonadal axis were examined in prepubertal, pubertal, and adult male rats exposed perinatally to BPA (BPA-rats). Here, we show that in postnatal d (PND)30/50/90 BPA-rats, the number of AVPV kisspeptin-immunoreactive cells was persistently increased in comparison with age-matched control male rats. The number of GnRH-immunoreactive cells in PND30 BPA-rats declined approximately 40% compared with control male rats, whereas that in PND50/90 BPA-rats was increased in a G protein-coupled

receptor 54-dependent manner. Estradiol could induce a stable LH-surge in PND90 BPA-rats and control female rats, which was sensitive to the G protein-coupled receptor 54 inhibitor. In PND30/50 BPA-rats, plasma level of LH was higher, but the level of testosterone was lower than control male rats. These findings provide SRT2104 inhibitor evidence that perinatal exposure to an environmental dose of BPA causes a sustained increase in AVPV kisspeptin neurons in male rats, leading to the generation of estradiol-induced LH-surge system. (Endocrinology 152: 1562-1571, 2011)”
“PURPOSE. We compared the choroidal thickness of the eyes of patients with acute primary angle-closure (APAC) with fellow eyes in the same patients.\n\nMETHODS. The analysis included 21 participants with unilateral APAC affected eyes and 21 fellow eyes with a diagnosis of primary angle-closure suspect (PACS).