11 and 12 There are studies that indicate overtraining athletes to this

decreased T/C ratio was associated with increased proteolysis and decreased protein synthesis.13 and 14 However, there are studies that found no correlation between this ratio and overtraining syndrome.15, 16 and 17 Despite the controversial role of this ratio, regular measurement is an indicator of the balance between catabolic and anabolic processes,13, 14 and 18 and suggests possible changes required in the training program of the athlete. Soccer beta-catenin inhibitor at a high level is a demanding sport. Apart from technique and tactics knowledge, the participants should also be sufficiently developed in all physical abilities. The training season in soccer lasts about 11 months. Approximately 2 months are the preparation period, 8 months represents the competitive season, 1 month is a transitional period and 1 month is the players’ holiday. In the re-building Ceritinib supplier period, the players try to improve their physical abilities. In the next phase (in season), they have to maintain these abilities at the highest level. To improve through training, the process should be a proper balance between the volume and intensity of training with

rest periods.19 A long recovery from training may not lead to optimal adjustments whereas limited recovery for a long time will probably lead to overtraining syndrome with all of its negative effects on the player’s performance and health.18, 19 and 20 Furthermore, the psychological stress that a player experiences during the season is an additional factor that can influence his physiological state. One way to protect the players is to regularly monitor the concentrations of testosterone and cortisol and their ratio during the course of the season.21, 22, 23, 24 and 25 The aim of this study was to analyze the testosterone and cortisol responses

in a professional soccer team that participates in a professional Greek league throughout aminophylline the season. To our knowledge, this research is the only study performed in professional soccer players over an entire season. We studied the changes in testosterone, cortisol, and their ratio throughout a soccer season. In this way, we studied the stresses provoked by exercise through a season of competition in professional players. The team participated in 30 matches for the championship, and five matches for the cup. Samples were collected before the beginning of the re-building period, just after the re-building period, at the middle of the season, and at the end of the season (Fig. 1). The samples were collected 24 h after different matches, at 8:00 am, in the fasting state. The blood samples were collected at rest. The measurements were assessed as part of the standard anthropometric/physical conditioning testing. At the beginning of the study, 25 male professional soccer players were enrolled. During the season, some of them were injured and lost some training sessions.