The incidence and mortality rate of lung FHPI solubility dmso cancer in China urban populations have reached the number one among malignant tumors. Although the incidence and death rate of lung cancer is now declining in men, the incidence and death rate in women continues to increase. So in this sense it is more important to study the impact factors of lung cancer in female population. Adenocarcinoma accounts

for about 40% of all lung cancer, with a higher incidence in women. It is the most frequent subtype occurring in those who have never smoked. The epidemiologic characteristics and risk factors of lung cancer in nonsmokers are not clear. As we know, many lung cancer patients didn’t have the history of smoking and a lot of smokers didn’t AZD1152 mouse develop lung cancer [1], suggesting that host susceptibility factors may play an important role in this disease. Recent genetic Selleck CHIR98014 susceptibility studies of cancer have focused on single nucleotide polymorphisms (SNPs) in candidate genes, among which DNA repair

genes are increasingly studied because of their critical role in maintaining genome integrity. Excision repair cross-complimentary group 1 and group 2 (ERCC1 and ERCC2) are the important DNA repair genes, playing critical roles in nucleotide excision repair (NER) pathway which is the most important system to repair a wide variety of structurally DNA lesions, including bulky adducts, cross-links [2], oxidative DNA damage, thymidine dimmers [3]and alkylating damage [4]. The two genes are all located in chromosome 19q13.2-13.3. ERCC2 codes for an evolutionarily conserved helicase, a subunit of TFIIH complex which is essential for transcription and NER. ERCC1 protein is responsible for recognition of DNA damage and removal of the damaged nucleotides in NER. SNPs in exons of DNA repair genes may influence their protein activity, resulting in differences of individual NER and

selleck chemical DNA repair capacity (DRC) that may affect the susceptibility of lung cancer. So we selected the common SNPs in exons of ERCC2 and ERCC1 gene and with the frequency of heterozygosity >5% in the present study. The common polymorphism of ERCC1 gene is at codon 118 (C > T substitution at exon 4, without amino acid change–Asn/Asn, rs11615). The common polymorphisms of ERCC2 gene is at codon 751 (A > C substitution at nucleotide position 35931, exon 23, Lys>Gln, rs13181) and codon 312 (G >A substitution at position 23951, exon 10, Asp>Asn, rs1799793). The polymorphisms at codon 312 and 751 have been studied extensively for their potential implication in cancer risk. The effect of the ERCC2 and ERCC1 polymorphisms, and also of the haplotypes encompassing these two genes, on susceptibility of lung adenocarcinoma in non-smoking females has not been reported so far.