In addition, as shown in Table 4, the relative percentage changes in WBC count accompanying exercise on both the first and last days of the training camp showed positive correlations with neutrophil Obeticholic counts and negative correlations with lymphocyte counts. Neutrophil and lymphocyte counts showed a negative correlation. In general, WBC count and neutrophil count are known to increase after intense exercise, while lymphocyte count is known to decrease, in athletes and healthy adults [14, 21]. Among the WBCs that increased after intense exercise, neutrophils induce inflammation, which is believed

to reduce lymphocyte count through pro-inflammatory cytokine and stress Daporinad cost hormone production, which in turn causes a reduction in immunological function [22–25]. The above observations suggest that the interval exercise bouts performed on the first and last days of the training camp induced an inflammatory state, thus reducing immunological function. Wee1 inhibitor In addition, no significant increase in WBC count was observed in the CT group on the first day of the training camp and the increase in neutrophil count and reduction in lymphocyte count accompanying exercise were significantly suppressed compared to the P group. These results indicate that CT intake

suppresses excessive increases in inflammatory reactions accompanying Sinomenine intense exercise, and thus suppresses the reduction of immunological function. Through analysis using mice, CT was shown to increase the levels of GSH in organisms, as well as increasing humoral immune responses and increasing antigen-specific antibody production [4]. NAC, a precursor

of GSH, was shown in clinical studies to significantly suppress the production of ROS from neutrophils increased through exercise [17–19]. These findings suggest that CT may suppress ROS production from neutrophils accumulated in skeletal muscles damaged through intense exercise, suppressing further accumulation of neutrophils and thus suppressing the excessive inflammatory reaction. Further, this suppression of excessive inflammatory reaction is believed to suppress the reduction of immunological function. To clarify these points, further analysis of GSH and ROS production from neutrophils in organisms during intense exercise as well as the effects of CT intake on oxidative stress are necessary. In this study, it is suggested that CT intake suppressed excessive inflammatory reaction on the first day of the training camp and suppressed reduction of immunological function. However, on the last day of the training camp, other than a tendency for CT intake to suppress increased WBC and myoglobin following the interval training workout, no significant effect was observed in comparison to the P group.