Confidence in these therapies. Thus, antipsychotics or cases in clinical practice in the treatment of choice in most cases, Despite its limited effectiveness, the severity of side effects, many patients and their off-label use. Although we do not examine the presence of Verhaltensst Requirements, CEP-18770 Proteasome Inhibitors the prescription of these drugs in patients treated with cholinesterase inhibitors probably closely related to these disorders context. All Zulassungsbeh have Earths Now asked Doctors, apply a more restrictive approach to evaluate and critique the relevance and the benefits and risks before prescribing these drugs for patients with dementia. The choice must reflect the approved indication, the type of Verhaltensst Requirements and Komorbidit t, the patient risks or S-indications to the Press Presence of cardiovascular disease, and R The OFA common prerequisite for the treatment of psychotic St disturbances.
However, show almost the H Half of patients with schizophrenia display an inadequate response to antipsychotic treatment in many patients and poor compliance as a result. In turn, this may be a clinical deterioration, including normal psychotic relapse. The factors influencing CCT128930 Akt inhibitor the Ver Change was in response to antipsychotic treatment is not well elucidated Rt. Inter-individual variability and t between the races in drug response Therapy may reflect se m for may have the genetic heterogeneity T and the presence of modifier genes. Several genetic association studies have been performed, the positive associations between reaction and polymorphisms in genes for dopamine, serotonin and some other systems.
In this study we have further to the answer to polymorphisms with antipsychotic drugs for Connected s patients only focus. Dopamine D2 receptor Oligomycin A blockade is a feature of all antipsychotics. The Taq1A polymorphisms downstream Rts of the dopamine D2 receptor gene is located, 141c and INS / DEL, is located in the promoter region of the DRD2, fits to the density of D2 receptors in the striatum. Several studies have associated TaqI A and 141C of the response to the first and second generation antipsychotics. The affinity t of some antipsychotic drugs for the D3 receptor F cases Only a part of their effect, although affinity t differ for the D3 receptor between them can k.
DRD3 Ser9Gly polymorphism is an amino Acid substitution in the N-terminal extracellular Ren receptor and the membrane expression of this receptor by Ver Change in the intracellular Mighty Ren maturation adversely. A positive correlation between the response to SGA and the presence of the Gly allele was found in three studies. Ver Have changes in the serotonergic system in the mechanisms of action of antipsychotic drugs with antagonist properties at serotonin receptors, especially serotonin receptor 2A and 2C, taken together. Two SNPs gene 5HTR2A been several studies on the association in response to clozapine. The results were contradictory. The 102 T / C SNP does not participate Non-amino uresubstitution, But in white Patients in linkage disequilibrium with the variant 1438A / G, which is in the gene promoter. The A allele of this polymorphism would be the in vitro activity t hen to the promoter increased. Polymorphism His452Tyr entered No functional Changes of the receptor that Change Tyr