A limited number of studies with conflicting results have investigated the association selleck products between polymorphisms in GST genes and mortality Inhibitors,Modulators,Libraries in breast cancer patients. The majority of these studied patients diagnosed prior to 1999. Five of six studies have samples of women undergoing chemo therapy and or radiotherapy, and most examined only one GST gene. Four of the six were based on small samples of pa tients N 240 250. One large study of 2430 breast cancer patients was comprised of women with early stage disease who were unlikely to have undergone chemotherapy, and found no association with the only GST examined and survival. One other large study of 1034 women from Shanghai, China, all treated with adju vant chemotherapy, found a reduction in risk with the vari ant GSTP1 Val allele but no association with Inhibitors,Modulators,Libraries either GSTT1 or GSTM1 and risk of death.

In two reports based on the Inhibitors,Modulators,Libraries same sample, women with breast cancer with null mutations Inhibitors,Modulators,Libraries for GSTM1 and GSTT1 had reduced risk of death compared to women with alleles present, and a reduction in mortality risk for women homozygous for the variant GSTP1 Val allele compared to those homozygous for the Ile allele. Fi nally, 2 other small studies examined associations be tween one GST polymorphism among women treated with high dose chemotherapy, one reported no associ ation between survival and GSTM1 null, another, that the GSTP1 Val Val polymorph ism was non significantly associated with worse overall survival. Two studies, reported an association between GSTT1 and GSTM1 null mutations and lower levels of the in flammatory biomarker CRP, itself associated with poor survival.

We thus examined this association in the Health, Eating, Activity and Lifestyle study. We extend prior research by examining the association between three different Inhibitors,Modulators,Libraries GST isoenzymes, and all cause and breast cancer specific mortality in a multi ethnic cohort of breast cancer survivors drawn from population based cancer registries. This sample of breast cancer patients diagnosed from 1995 1999 includes a larger number of women undergoing chemo therapy and or radiotherapy than most prior studies and reflects more contem porary therapy regimens than those based on women treated in the mid 1980s mid 1990s.

Materials and methods Study setting, participants, and recruitment The HEAL Study is a multicenter, multiethnic prospect ive cohort study which enrolled 1,183 women diagnosed with breast cancer, to evaluate effects of diet, weight, physical activity, lifestyle, hormones or other exposures on breast cancer prognosis. Aims, study design and re cruitment procedures selleck inhibitor have been published previously. Briefly, women were recruited through Surveillance, Epidemiology, and End Results registries in New Mexico, Los Angeles County, and western Washington. Baseline surveys were conducted on average 6 months post diagnosis.