51, P = 0.0015) selleck catalog (Figure ?(Figure3).3). After accounting for HV, the correlation persisted (r = -0.49, P = 0.015). Figure 3 Relationship between ??-amyloid burden and episodic memory in mild cognitive impairment. There was a significant correlation between ??-amyloid (A??) burden and memory impairment, which was independent of hippocampal volume. Dotted … There was also a relationship between HV and EM in the entire MCI cohort (r = 0.60, P = 0.024). Accounting for neocortical SUVR, the correlation between HV and EM also remained significant (r = 0.33, P = 0.042) for the entire MCI cohort. There was a relationship between WMH volume and nonmemory z scores (r = -0.60, P = 0.03; Spearman’s ?? = -0.48, P = 0.0008). This correlation was amplified in the high SUVR subgroup (r = -0.71, P = 0.

014; Spearman’s ?? = -0.57, P = 0.0035), but was not present in the low SUVR subgroup (see Figure S1 in Additional file 2). No correlation was found between WMH and neocortical SUVR, HV or EM. Discussion A?? burden and memory impairment This study provides support for the use of FBB PET to assess brain A?? plaque levels in individuals with MCI. FBB presents with similar characteristics to PiB, including short scan acquisition time and a good safety and tolerability profile. The longer radioactive half-life of fluorine-18 makes FBB PET a promising Brefeldin_A clinical tool for the detection of AD pathology in vivo. The observation that 53% of scans had high FBB retention is consistent with the prevalence of AD neuropathology at postmortem in those with MCI or in those who progress from MCI to dementia [39,40] and with reports that have used PiB PET or cerebrospinal fluid measures to assess brain A?? in MCI [41-43].

There was a strong correlation between FBB retention and episodic memory impairment, the cognitive domain that is the best predictor of AD [44]. In contrast to several A?? imaging studies using PiB [33,45], we found the correlation to be independent of HV – suggesting that selleck Idelalisib A?? might have a direct effect on memory storage and retrieval. This is supported by functional MRI studies of the default network that have shown a relationship between regional A?? tracer retention and disrupted synaptic activity well beyond the hippocampus in neuronal memory circuits [46]. Despite the multifaceted nature of memory and other cognitive domains affected by a wide spectrum of physical and environmental factors, the arbitrary distinction of single-domain amnestic MCI from multidomain amnestic MCI appears to increase confidence of in vivo AD pathology. In our cohort, approximately 80% of asMCI presented with high FBB retention.