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PI3-K-PKB-mTOR signaling properties aper-U-structural PI3 PI3-K-in KS are three major categories according to their e sequence homology sections: I, II and III. Class I PI3-K have the majority of the research interests of proteins Heterodimers and tightened with a catalytic subunit and regulatory requirements. The catalytic subunit of 110 kDa composed of a lipid-catalytic domain Ne a Ras-binding Ne, a C2-Dom Ne phospholipid binding, a Kinasedom Ne helicopter Dale PI and an N-terminal domain Ne, which forms a bond sealed with the regulatory subunit. Class I PI3-K and J Biol Chem 1:49 2 � DOI 10.1007/s12154-008-0008-0 RM Gunn HC Hailes departure