“
“We investigated a possible association of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) Gly482Ser polymorphism with hypertension in Mongolians in Inner Mongolia. A total of 787 subjects were enrolled randomly, including 390 hypertension patients and 397 healthy controls. Triglycerides, cholesterol, and fasting

plasma glucose were measured, and body mass index was calculated. PCR-RFLP was used to analyze Gly482Ser polymorphisms. There were significant differences in triglycerides, fasting plasma glucose, and body mass index between hypertension patients and healthy controls. Cholesterol levels did not differ significantly. The PGC-1a gene GG, GA and AA genotype distributions were 37.2, 48.5 and 14.4%, respectively, in patients and 48.6, 37.3 and 14.1% in healthy controls. The frequencies of PGC-1a genotype GA Anlotinib cost and allele A were significantly different between hypertension patients and healthy Mongolians. We concluded that PGC-1 alpha Gly482Ser polymorphism is associated AZD1480 with hypertension in Mongolians in Inner Mongolia.”
“We report (001)-oriented

FePtAg-C nanogranular films consisting of fine particle size of about 5 nm with a narrow size distribution of 3.3 nm in variance that were grown on a Fe-Ta-C nanocrystalline soft magnetic underlayer (SUL) through MgO/SiO(2) intermediate layers. The degree of L1(0) order, c-axis orientation and resulting magnetic properties of FePtAg-C nanogranular films grown at low temperatures are improved by the post annealing effect without changing the nanogranular microstructure dramatically. Square-shaped perpendicular hysteresis loops with large negative nucleation field of 3.8 kOe, 100% squareness, coercivity of similar to 8 kOe, and high energy barrier of 2.13 eV were obtained for the double-layered medium. Temperature dependent Kerr loops measurement reveals that the coercivity and nucleation field decrease at a rate of 26 Oe/degrees C and 20 Oe/degrees C, respectively. These results suggest that the (001) textured FePtAg-C nanogranular films with perpendicular anisotropy

on SUL may be suitable as a recording medium to realize ultrahigh-density perpendicular recording in the conventional recording system. (C) 2010 American Institute GF120918 of Physics. [doi:10.1063/1.3487978]“
“An important aspect of the functional annotation of enzymes is not only the type of reaction catalysed by an enzyme, but also the substrate specificity, which can vary widely within the same family. In many cases, prediction of family membership and even substrate specificity is possible from enzyme sequence alone, using a nearest neighbour classification rule. However, the combination of structural information and sequence information can improve the interpretability and accuracy of predictive models.