The TSST-G provides a novel, effective, and economical protocol for experimental paradigms requiring simultaneous stress induction in multiple participants. (c) 2010 Elsevier Ltd. All rights
reserved.”
“Objective: To determine the effect of AT1 receptor antagonism on skin microcirculation and plasma level of thromboxane A(2) (TXA(2)). Methods: Healthy women (n=20) maintained 7 days low salt (LS) diet (intake <40 mmol Na/day) without (LS) or together with 50 mg/per day of losartan (a selective AT1 receptor inhibitor) (LS diet+losartan group). Laser Doppler flowmetry (LDF) measurements of changes in post occlusive hyperemic blood flow, plasma concentration of stable TXA(2) metabolite, thromboxane B-2 (TXB2) and plasma renin activity (PRA), aldosterone concentration, electrolytes (Na+, K+), as well as blood pressure and heart rate were determined before and after study protocols. this website Results: PRA and aldosterone increased significantly after 7 days of both LS diet and LS diet+losartan. LS diet or LS diet+losartan administrations GSK2879552 mw had no significant effect on post-occlusion hyperemia. While there was no change in TXB2 after LS diet, TXB2 significantly increased after one week of LS+losartan compared
to control levels (cTXB2 pg/mL control 101 +/- 80 vs. LS diet+losartan 190 +/- 116, p<0.05). Conclusion: These data suggest that inhibition of AT1 receptors could lead to activation of AT2 Bortezomib cell line receptors, which maintain hyperemia, despite the increased level of vasoconstrictor TXA(2). These findings also suggest an important role of crosstalk between renin-angiotensin system (RAS) and arachidonic acid metabolites in the regulation of microcirculation under physiological conditions. Copyright (C) 2013 S. Karger AG, Basel”
“Premenstrual syndrome (PMS) is characterized by a cluster of psychological and somatic symptoms that begin during the late luteal phase of the menstrual cycle and disappear after the onset of menses. Since PMS might
be caused by an alteration in the cyclical hormonal modifications and ovarian steroids are directly involved in the regulation of mood, affective and cognitive functions and influence neurotrophins expression, in particular the brain-derived neurotrophic factor (BDNF), we aimed to evaluate whether plasma BDNF levels in women with PMS differ from those of normally menstruating women without PMS. Sixty-two women were divided into two groups: one group of women (n = 35) with PMS and one group (n = 27) composed by normally menstruating women. Plasma samples were collected at day 7 (follicular phase) and day 21 (luteal phase) of the menstrual cycle. Plasma BDNF of the control group significantly increased (p < 0.001) from the follicular phase (402.90 +/- 74.41 pg/ml) to the luteal phase (1098.79 +/- 146.49 pg/ml). On the other hand, in the PMS group plasma BDNF levels significantly decreased ( p < 0.