She also reported blurred vision. Examination revealed drooping buy PLX4032 of both eyelids. Computed tomography and Magnetic resonance imaging of the head did not detect abnormal findings. Chest CT showed right lower lobe pneumonia, no

thymoma was present. Subsequent positive Neostigmine test confirmed a diagnosis of myasthenia gravis (MG). Conclusion: In conclusion, our case report together with other evidence, suggests the association between CD and MG is potential instead of coincidental. Further study is needed to investigate the exact coexistent mechanism between these two diseases. Key Word(s): 1. Crohn’s disease; 2. Myasthenia Gravis; 3. Mechanism; 4. Association; Presenting Author: CHENJIAN YONG Corresponding Author: CHENJIAN YONG Affiliations: The people’s hospital of Jianxi Province Objective: To explore the effects of Lipopolysaccharide (LPS)/inhibitor of calcium/ calm- odulin-dependent protein kinaseII (KN62) pretreatment on colitis of BALB/C mice animal model

induced by trinitrobenzene sulfonic RXDX-106 acid. Methods: BALB/C mice were randomly assigned to four groups: normal control group (NC group), model control group (UC group), LPS group and KN62 group. Except that the normal control group was administered intracolonically with saline, the other groups were administered intracolonically with Trinitrobenzene sulfonic acid ethanol solution to construct colitis model. Mice of the LIProupalso received intraperitoneal injection of Lipopolysaccharide, KN62 group received intraperitoneal injection of KN62, while the model control group received intraperitoneal injection of saline. The disease activity index (DAI) and histological index (HI) were calculated, the expression of IL-6mRNA in the intestinal mucosa was measured by reverse transcription Polymerase

Chain Response (RT-PCR), the expression level of Mouse MHC-II molecules in the Lamina propria. was measured by Flow cytometry. Results: From the results we can find that the DAI score, HI score, Isotretinoin the expression of IL-6mRNA, the level of MHC-II with NC group compared with UC group had statistical difference (P < 0.05), LPS group compared with UC group had statistical difference (P < 0.05) KN62 group compared with UC group had statistical difference (P < 0.05). Conclusion: Treatment with KN62(25 ng/mouse), DAI, HI, the expression of IL-6mRNA in the intestinal mucosa and the expression level of Mouse MHC-II molecules in the Lamina propria of mice with experimental colitis decreased indicates KN62 can attenuate the inflammation and be useful for protection to host. Key Word(s): 1. TNBS; 2. Inflammatory bowel; 3. Lipopolysaccharide; Presenting Author: XIAOSAN ZHU Additional Authors: YICHEN DAI, ZHANGXING CHEN, YUANYUAN LIN Corresponding Author: XIAOSAN ZHU Affiliations: The 174th Hosptial of the PLA Objective: To study the clinical and endoscopic characteristics of ulcerative colitis.