Kinetin blood pressur while no significant change was observed in the control group . No serious procedure related or device relatedplications occurred. A follow up study of patients who underwent renal nerve ablation showed that postprocedure blood pressures remained below baseli by mmHg after months and by mmHg after mont suggesting a persistent effect of the procedure. Although these results are encouragi further studies are required to clarify several factors that might affect the efficacy of renal denervati including patient eligibility criter the need for continued drug treatme the number of drugs required to keep blood pressure controll and the potential for achieving long term blood pressure reduction in view of the loss of renal sympathetic activity and the possibility of renal  Macmillan Publishers Limited.

All rights reserved REVIEWS re innervation. Initial data from animal experiments suggest Rucaparib 459868-92-9 that renal re innervation might occur; in rats re innervation wasplete and functional at weeks after renal denervati whereas in dogs functional re inner vation wasplete months after the procedure. Howev although it is evident that human kidney undergoes re innervation after renal transplantati this re innervation might be nonfunctional and the extent to which re innervation could affect the oue of renal denervation in humans remains unclear. As the blood pressure lowering effect of the procedure per sists months after denervati a longer follow up is required to answer this question and increase our knowledge of re innervation in human kidney.

Chemical denervation with locally applied vincristine has also been suggested as a buy Cabozantinib method of renal sympa thectomy. Howev further data are needed to show whether this approach will be better tolerated by patients than radiofrequency ablati and to determine whether the beneficial effect will be as durable. Electrode BAT device BP BP Baroreceptor activation Baroreflex activation therapy is a device based approach to treating hypertension that has been inten sively investigated. The BAT device consists of an implantable pulse generator that activates the carotid sinus via an electrical sign delivered by bilateral leads. The leads are implanted during open surgery and the electrodes are positioned at the areas of greatest response in the carotid sinus. Stimulation of the sinus by the BAT device supplies the blood pressure control centers Silybin B inhibitor with false information of increased blood pressu leading to reflexive blood pressure lowering .

Data from the DEBuT HT tri which assessed BAT in patients with hypertensi showed that of patients had a reduction in systolic blood pressure of at least mmHg after years of treatment . The mean reduction in diastolic blood pressure at years was mmHg and the drop in heart rate averaged bpm against baseline. The average number of anti ascorbic acid hypertensive medications used decreased from at baseline to over the same time period. A large phase I double bli random iz prospecti multicent placebo controlled study of the same device confirmed the efficacy and safety of BAT in patients with resistant hypertension. The results showed that target systolic blood pressure values of mmHg were achieved in of patients who received months.