“
“Despite its strong anti-tumor activity against human cancers, paclitaxel (Taxol (R)) suffers limited clinical applications due to the low aqueous solubility and lack of appropriate delivery vehicles. In an attempt to develop an alternative formulation of paclitaxel suitable for parenteral

administration, paclitaxel-loaded lipid nanospheres were constructed as colloidal carrier system for controlled drug delivery. Alpha-tocopheryl succinate (alpha-TOS), a semi-synthetic vitamin E analog, was employed as a new physiological acceptable lipid material to prepare nanoparticulates. A novel bottom-up process was performed by a modified spontaneous emulsification solvent-diffusion method, which is suitable for large industrial scale production. The influence of key parameters such as temperature and surfactant concentration on the size and uniformity of the distribution of nanospheres were DMH1 research buy investigated. Spherical particles with similar to 100 nm of mean diameter and 90% of drug entrapment efficiency were obtained under optimal conditions. Physicochemical characterization of the particles reveals a molecular dispersion of paclitaxel in the lipidic matrix. The in vitro release behavior of paclitaxel from the developed nanospheres was characterized by an initial fast release, followed

Navitoclax chemical structure by a sustained release up to 72 h. The release mechanism suggests that paclitaxel release from the vehicles was dual controlled by both the diffusion of drug and corrosion of lipid matrix. These results demonstrate the”
“The free-radical-initiated copolymerization of 2-(4-acetylphenoxy)-2-oxoethyl-2-methylacrylate

(AOEMA) and 2-(4-benzoylphenoxy)-2-oxoethyl-2-methylacrylate Evofosfamide datasheet (BOEMA) with 2-[(4-fluorophenyoxy]-2-oxoethyl-2-methylacrylate (FPEMA) were carried out in 1,4-dioxane solution at 65 degrees C using 2,2′-azobisisobutyronitrile as an initiator with different monomer-to-monomer ratios in the feed. The monomers and copolymers were characterized by FTIR and (1)H- and (13)C-NMR spectral studies. (1)H-NMR analysis was used to determine the molar fractions of AOEMA, BOEMA, and FPEMA in the copolymers. The reactivity ratios of the monomers were determined by the application of Fineman-Ross and Kelen-Tudos methods. The analysis of reactivity ratios revealed that BOEMA and AOEMA are less reactive than FPEMA, and copolymers formed are statistically in nature. The molecular weights ((M) over bar (w) and (M) over bar (n)) and polyclispersity index of the polymers were determined using gel permeation chromatography. Thermogravimetric analysis of the polymers reveals that the thermal stability of the copolymers increases with an increase in the mole fraction of FPEMA in the copolymers.