(C) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.”
“Spontaneous bacterial peritonitis (SBP) is a frequent and severe complication that occurs in patient with cirrhosis and ascites. It occurs in 10% to 30% of patients admitted to hospital. The organisms that cause SBP are predominantly enteric. Escherichia coli is the most frequent recovered pathogen, and Gram-positive bacteria, mainly Staphylococcus spp., are being considered an emerging causative agent of LY2835219 nmr SBP. Streptococcus bovis that may be found as part of the commensal bowel flora in
about 10% of healthy adults constitute an uncommon cause of peritonitis that was first reported in 1994. We describe the first case of SBP at the University Hospital of Santa Maria (HUSM) caused by S. bovis, resistant to the antibiotics erythromycin and clindamycin (inducible Liproxstatin-1 clindamycin resistance detected by disk diffusion test using the D-zone test).”
“The absolute configuration of dilospirane B (1), a diterpene featuring a novel carbon framework recently isolated from the brown alga Dilophus spiralis, was established on the basis of theoretical calculations of its electronic circular dichroism spectra applying the time-dependent density functional theory method. Metabolite
1, evaluated for its in vitro antitumor activity against six human cancer cell lines displaying various levels of sensitivity to pro-apoptotic stimuli, exhibited growth inhibitory activity with a mean IC50 value of 66 mu M. Quantitative videomicroscopy analyses indicated that 1 initially displays cytostatic effects which later become cytotoxic. (C) 2012 Published by Elsevier B.V. on behalf of Phytochemical Society of Europe.”
“Monoclonal gammopathy can accompany diverse conditions and is usually benign. It should be distinguished from monoclonal gammopathy of undetermined significance (MGUS) which can rarely turn malignant. Visceral leishmaniasis has only rarely been associated with monoclonal gammopathy. We describe
the case of a Elafibranor manufacturer 55-year-old male who had monoclonal gammopathy associated with visceral leishmanisais, which reversed with stibogluconate therapy.”
“A new triterpeniod saponin 3-O-beta-arabinopyranosyl-(1 -> 3)-[beta-galactopyranosyl-(1 -> 2)]-beta-glucuronopyranosyl gypsogenin (1), together with the known saponin 3-O-beta-xylopyranosyl-(1 -> 3)-[beta-galactopyranosyl-(1 -> 2)]-beta-glucuronopyranosyl gypsogenin (2), and three known triterpenes gypsogenic acid (3), quillaic acid (4) and gypsogenin (5) were isolated from the roots of Gypsophila trichotoma Wend. (Caryophyllaceae). Their structures were elucidated by chemical and spectral methods. Cytotoxic activity of compounds 1 and 2 were tested against seven human cancer cell lines. Compound 1 showed cytotoxic activity against all of them, while compound 2 only against two cell lines. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B.V.