Brachial artery diameter was measured before and after cuff occlusion using high-resolution ultrasound. Peak VO2 was measured using expired gas analysis during upright cycle exercise.

Results. Peak VO2 was severely reduced in older HFpEF patients compared with age-matched healthy participants (15.2 +/- 0.5 vs 19.6 +/- 0.6 mL/kg/min, p < .0001), and in both groups, peak VO2 was reduced compared with young healthy controls (28.5 +/- 0.8 mL/kg/min; both p < .0001). Compared with healthy young participants,

brachial artery FMD (healthy young, 6.13% 4-Hydroxytamoxifen +/- 0.53%) was significantly reduced in healthy older participants (4.0 +/- 0.38; p < .0002) and in HFpEF patients (3.64% +/- 0.28%; p < .0001). However, FMD was not different in HFpEF patients compared 4SC-202 with healthy older participants (p = .86). Although brachial artery FMD was modestly related to peak VO2 in univariate analyses (r = .19; p = .048), it was not related in multivariate analyses that accounted for age, gender, and body size.

Conclusion. These results suggest that endothelial dysfunction may not be a significant independent contributor to the severely reduced exercise capacity in elderly HFpEF patients.”
“Adoption of a standard depression measures across clinics and populations is advantageous for continuity of care and facilitation of research. This study

provides information on the comparative utility of a commonly used perinatal-specific depression instrument (the Edinburgh Postnatal Depression Scale-EPDS) with a general depression screener (Patient Health Questionnaire-9-PHQ-9) in a sample of perinatal women seeking psychiatry services within a large health care system. Electronic medical records (which included PHQ-9 and EDPS) were abstracted for a final sample of selleck kinase inhibitor 81 pregnant and 104 postpartum patients (n = 185). Psychometric properties were examined among women who met the criteria for Major Depressive Disorder (MDD) based on clinician diagnoses, as compared to women without any mood disorder diagnosis. Using commonly recommended

cut-off scores, both measures had comparable sensitivity, specificity, PPV and NPV for both pregnant and postpartum women. Comparative AUC for ROC contrasts were not significantly different between the two measures. Thus, this study found few significant differences in the performance of the PHQ-9 and EPDS in detecting clinician-diagnosed MDD in a psychiatry outpatient sample of pregnant and postpartum women. Published by Elsevier Ireland Ltd.”
“Background. Sarcopenia defined by lean mass has been inconsistently associated with disability in elders. Studies suggest that definitions should consider body size and additional influences of high fat mass (FM; sarcopenic-obesity). We examined sarcopenia accounting for body size, and sarcopenic-obesity, in relation to mobility limitations among 767 elderly men and women (mean age 79 years) from the Framingham Study.

Methods.