{C 2, C3, representing stochastic rate constants. In addition, the rate laws HIEX cit, where I joined some kind of reaction, and X ~ eXDSB, XRP, XDSBC XRDSBT is the current response of each species) of the system. These chemical reactions stochastically, and fluctuations in the number of molecules that are produced in these axitinib AG-013736 reactions are stochastic processes. For example, the production of CBD a zero order reaction, and the danger of reaction is h1eX, C1T ~ c1: E2T The DSB repair process is a second order reaction, and the combined risk of reaction is 2 x 2 2 Hz __ ~ CZ CZ XDSBXRP: E3T The repair failed and successful reactions are first order, and we call the combined risks of each reaction over 2 h {X, {c 2 __ ~ c {2 XDSBC, E4t h3eX, C3T ~ c3XDSBC: The above equations E5T erm resembled us, Xi for each molecular type I with the Gillespie algorithm to calculate.
For example, a Change over time XDSBzXDSBC is shown in Figure 1. A schematic representation of the mechanism for recognition of the DSB in Dependence Of ATM. Abbreviations DSB: DNA double strand break; RP: repair protein, DsbC: DNA double-strand SGX-523 break repair proteins and complex RDSB: DSB repair. Asterisks indicate phosphorylated proteins. I mean, a repressor by the ATM. Some stress signals, induced by CBD PR to be repaired. ATM recognizes and DSBCs CBD, it is phosphorylated. The red arrow shows the autophosphorylation of ATM, the verst the signal of stress RKT. The dashed arrows indicate a negative feedback loop. We consider primarily the process of repair of the DSB and the sensor module of the ATM.
We refer to the negative feedback effect of p53 in the discussion. The information provided in the text. doi: 10.1371/journal.pone.0005131.g001 A model for ATM PLoS ONE sensor | Published in PloSOne second April 2009 | Volume 4 | Issue 4 | Figure 2 e5131 If there are many repair proteins, the number of Bezirksschulr-run DSBCs and fluctuating, with a mean m, standard deviation and 20 s, 4.5. Comparison of theoretical and simulation results in this section, we compare the results of the simulation and theoretical average values of CSD and DSBCs. A method for calculating theoretical values of the mean CSD and DSBCs in Materials and Methods section shown. The exact mechanism of DNA-Sch The processes by stress-induced signals are not VER Published, clarified Rt and k we can Not COLUMNS SECT, The stochastic rate constants.
In this paper, we assume that the stochastic rate constants CZ 2, {C2, C3, and not affected by stress signals, and their values are defined in Table 1. Furthermore, we assume that the parameter C 1 is proportional to the force of stress signals: c1 ½ Stress_: e6T For example, if we consider the parameter c 1 ~ 10 and ~ 100 Xmax RP, we DISABLE the average number of tips COLUMNS k can DSBCs and school district. Then is the time until the ann XDSBeCT the average hert in the form ^ X ~ XDSB 0:525, e7T ^ X ~ XDSBC 20:00 E8T tDSBC * 2-0, * E9t TDSB 0:0525: Figure 3 shows the comparison E10T between simulation and theoretical results. The E ½ XietT_: the ensemble average of X at time t. In Figure 3A, we see that E ½ XDSBetT_ converges to the steady state, but its value is a little different than the theoretical value.
The time to be closing any station Safe state De gr He is than the theoretical value. In Figure 2 Results of the simulation of the process of DSB repair. An evolution over time the number of Bezirksschulr-run and DSBCs with the expectation function of time and the standard deviation. Blue lines M6S. The histogram of the number of Bezirksschulr-run and DSBCs at time t = 100 In these figures, the maximum number of repair proteins RP Xmax ~ 1000. Other parameters are defined in Table 1. The initial number of molecules X0 X0 ~ ~ ~ DSB DsbC RDSB 0 X0, X0 and Xmax ~ RP RP. doi: 10.1371/journal.pone.0005131.g00