Another possible explanation may be attributed to the inclusion criteria in this study. Patients included in the study had to have the ability to walk independently or with an assistance device/spot www.selleckchem.com/products/U0126.html guarding for at least 10 meters. Consequently, they may have had sufficient quadriceps strength, with a lower tendency for ��knee crouch,�� in order to meet this demand.The daily use of a multichannel FES is not trivial. Difficulties may arise in relation to factors such as electrodes positioning, user interface, and overall convenience. Yet, the participants’ feedback about the device used in the present study was very positive, with no major difficulties reported in regard to operating the system or placing the stimulation cuffs.

The majority of the subjects rated the dual-channel system as the most useful system for assisting in their gait and function (78%) and were enthusiastic about continuing to use it (87%). Despite the benefits, however, the use of this device has several restrictions. The location of the thigh cuff under the clothing may be cumbersome for some patients. In addition, skin irritation might develop after prolonged use with electrical stimulation.This study has several limitations, including the protocol duration of six weeks, the lack of a control group, and the nonnormal distribution of the results. Further investigations should be undertaken to confirm the study results with appropriate control groups and longer durations of use. It is also possible that a larger and more homogenous sample in terms of gait ability prior to the intervention would have resulted in more normally distributed results enabling a more comprehensive analysis.

Finally, kinetic and kinematic studies may be useful in understanding the underlying mechanism of the effects of dual-channel FES. The promising results of the present investigation suggest that such studies are warranted.5. ConclusionsFunctional electrical stimulation is an accepted treatment method for paresis or paralysis after Dacomitinib stroke, as well as for other neurological upper motor neuron disorders. In the past, implementation of FES focused primarily on the stimulation of ankle musculature. The findings of this study suggest that the application of FES which is intended to assist with ankle and knee activation may further improve the temporal characteristics of gait in patients who demonstrate insufficient knee control in addition to foot-drop. Thus, the results of this study may lead to a more effective application of FES technology.DisclosureS. Springer and R. Lipson are employed by Bioness Neuromodulation, the manufacturer of the L300Plus. This work was supported in part by Bioness Neuromodulation.
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