00 ng/ml [3.65-6.35]; p=0.007). PNPLA3 levels correlated to BMI (r=0.382; p<0.005), leptin levels (r=0.681; p<0.0005), and inversely to resistin (r=-0.278; p<0.05) and AST levels (r=0.168; p<0.05). Patients with biopsy-proven NASH showed lower serum level of PNPLA3 in comparison with simple steatosis (mean [95% CI]; 4.38 ng/ml [2.47-6.29] signaling pathway in NASH versus 9.20 ng/ml [4.15-14.23] in simple steatosis; p=0.006). A serum level > 10.7 ng/ml showed 32% sensitivity and 82% specificity to predict a simple steatosis according to ROC curve analysis (AUROC 0.68 [95% CI: 0.55-0.81]; p=0.01). Conclusions Serum levels of PNPLA3 correlated with steatosis degree but not with steatohepatitis. As previously

reported about the variant I148M, adiponutrin seems to play a critical role in fat deposition but not in steatohepatitis progression. Further studies are warranted to demonstrate if previous association with fibrosis and NASH in NAFLD are pathogenic or consequence of the impact of confounding factor linked to the degree of fat infiltration. Disclosures: Manuel Romero-Gomez – Advisory Committees or Review Panels: Roche Farma, SA., MSD, S. A., Janssen, S. A., Abbott,

S. A.; Grant/Research Support: Ferrer, S. A. Javier Crespo – Board Membership: MSD, Roche, Janssen, Gilead The following people have nothing to disclose: Maria Teresa Arias-Loste, Paula Depsipeptide in vitro Iruzubieta, Angela Puente, Susana LLerena, Marcos López-Hoyos, Maria Teresa Garcίa-Unzueta, Rocίo Gallego-Durán, Isidora Ranchal, Javier Abad, Jose Luis Calleja, Carmelo Garcla-Monzon, Jose Luis Olcoz Non-alcoholic Fatty Liver Disease (NAFLD) disproportionally affects Hispanics compared to other racial/ethnic groups; however, prior studies have focused primarily on those of Mexican heritage. This study aimed to evaluate prevalence of suspected NAFLD among the diverse Hispanic/Latino participants of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Methods: Participants were 16, 415 adult men and women. Suspected NAFLD was defined as either AST >37 IU/ml or ALT >40 IU/ml for men, and either AST or ALT >31 find more IU/ml for women

in absence of another known cause of liver disease. Those with missing variables of interest, positive HBV/HCV serology, excessive alcohol consumption, or transferrin saturation >50% were excluded. Information on components of metabolic syndrome, acculturation, health care use, sleep quality, diet, physical activity, education and income was obtained. Results: 11, 753 participants were included. The Table shows prevalence of suspected NAFLD. It was most common with Mexican and Central American background and in men (23.1% vs women 15.6%, p<0.001). Suspected NAFLD was positively associated with age <40, and each component of metabolic syndrome. No associations with acculturation, health care use, sleep disturbance, physical activity or income were observed.