12 (0.07-0.21) and 0.90 (0.58-1.41). However, the significantly increased incidence rates PS-341 order were not observed for other subtypes. Women seropositive for HBsAg had relatively minor increases in the incidence rate of “small lymphocytic lymphoma and mantle cell lymphoma” and “mycosis fungoides

and Sezary’s disease” than HBsAg-seronegative women. On the contrary, the incidence rates of follicular lymphoma and peripheral T-cell lymphoma were higher among HBsAg-seronegative women compared with HBsAg-seropositive women. All eight cases of Burkitt lymphoma and the single case of NK/T-cell lymphoma were HBsAg-seronegative, whereas the single case of lymphoplasmacytic lymphoma was HBsAg-seropositive. Table 3 shows age-adjusted HR of ICC, NHL, and NHL subtypes comparing HBsAg-seropositive with HBsAg-seronegative parous women. The cumulative incidence of ICC, NHL overall, and diffuse large B-cell lymphoma are presented in Figs. 1, 2, and 3, respectively. Risks of these RG7204 research buy three cancers were higher in HBsAg-seropositive than in HBsAg-seronegative women throughout the period of follow-up. The risk for ICC among HBsAg-seropositive women was nearly 5-fold that among HBsAg-seronegative women (HR, 4.80; 95% CI, 1.88-12.20; Fig.

1). The risk for NHL was less strong but still more than double among HBV-infected women compared with HBV-uninfected women (HR, 2.63; 95% CI, 1.95-3.54; Fig. 2); stronger association was observed for diffuse large B-cell lymphoma (HR, 3.09; 95% CI, 2.06-4.64; Fig. 3) and other NHL (7.63; 3.70-15.74). On the contrary, the HBsAg serostatus was not associated with other major NHL subtypes, including follicular lymphoma, peripheral T-cell lymphoma, small lymphocytic lymphoma and mantle cell lymphoma, and mycosis click here fungoides and Sezary’s disease. After considering both HBsAg and HBeAg serostatus, compared with noncarriers, the HRs of carriers with HBeAg-seropositivity were higher than the HRs

of those with HBeAg-seronegativity for ICC, NHL overall, and diffuse large B-cell lymphoma. The corresponding age-adjusted HRs (95% CI) were 9.58 (2.54-36.04) and 5.40 (1.79-16.25) for ICC; 3.46 (2.08-5.75) and 2.20 (1.45-3.33) for NHL overall; and 4.66 (2.44-8.88) and 2.29 (1.28-4.10) for diffuse large B-cell lymphoma. However, the differences in age-adjusted HRs between HBeAg-seropositive and HBeAg-seronegative women were not statistically significant. The main finding of this nationwide, population-based retrospective cohort study of parous women from Taiwan was the substantially increased risk for ICC and NHL associated with markers of chronic HBV infection. Furthermore, with the large number of NHL cases with subtype information identified in this large population, we were able to demonstrate that HBV infection was most strongly associated with an increased risk of diffuse large B-cell lymphoma, but not with other specific NHL subtypes.