Tion routes, transfer, eg through the serine / threonine kinase may act Alternatively shore cell tumor growth from the root or Preferences, The cancer does not express the AR will be easier, but be of androgen ablation therapy, such as the nature of the primary Rtumor cell Selected hlt. Alternatively, the AR can be a variety of ways, the ligand-independent-Dependent egfr activation is it an M Possibility that regulate cell survival, activated lend in the absence of ligand. One of the main reasons for the reactivation of the cancer F promotion Pathways in cells, the phosphatidylinositol-3-kinase AW treated. This pathway l St a number of downstream targets such as Akt, which survive the cell f paths Promoted. Stimulation of these pathways prevents cell death w During treatment AW.
As receptor of the ErbB family known which PI3K signaling pathway is activated and regulate Transkriptionsaktivit t Independently of AZD6244 AR ligands Of one another are the following pages we will, like ErbB receptors regulate the progression of CRPC. Third GLANCE OVER erbB receptors, STRUCTURE AND activating ErbB family consists of four closely related receptor tyrosine kinase transmembrane 1: epidermal growth factor, ErbB2, ErbB3 and ErbB4. ErbB family signaling regulates many cellular Re activity Th important for the survival and the cellular Re function, including normal cell division, migration, adhesion version, Differentiation and apoptosis. EGFR and HER2 has been described in many excellent reviews and therefore will be described briefly here. 3.1.
ErbB receptors by ligand binding, dimerization and phosphorylation of the ErbB receptors ligand-activated chymal Messines are including normal heregulins and neuregulins and other epidermal growth factor activated as ligands. The 4 ErbBs share an overall structure of two cysteine-rich Dom NEN their extracellular and intracellular Ren region Re Kinasedom Ne, with a carboxy-terminal tail with tyrosine autophosphorylation sites flanked. Although it is essentially the same structure Dom ne, the functional activity of t Each variable. ErbB 1, 2 and 4 were active tyrosine kinase Dom NEN and ErbB 1, 3 and 4 have known ligands. 2 ErbB ligand is unknown, but is constitutive of the dimerization. ErbB 3 can bind several growth factors, but until recently it was not the intrinsic F Believed ability of tyrosine kinase.
Recent studies have refuted this view and is sp Ter described in this article. Homo or hetero receptor dimerization is important for the function and activity of t Of ErbB signaling. ErbB normally exist as monomers with inactive regions homodimerization folded to prevent dimerization. The binding of a specific ligand induces a conformational In the monomer and preparation for the dimerization of ErbB change a second ErbB active monomer. The exception may be ErbB2, which is thought to be activated fa Constitutive and is prepared for heterodimerization. Several different homodimer and heterodimer pairs between the four receivers Ngern possible to change only slightly with respect to maintain homodimers to heterodimers signals. This ligand-induced dimerization activates the receptor tyrosine kinase activity of t leads to internal and partner transautophosphorylation monomers. Adapter proteins Are recrui