We investigated Aloxistatin in vitro the effect of parameters of classical indication for CRRT on mortality in patients on continuous renal replacement (CRRT) therapy. Methods: We prospectively and consecutively enrolled a total of 519 patients who stared renal replacement therapy. Results: Mean age was 63.4 ± 14.5 years old, and men were 59.5%
in all enrolled patients. Causes of acute kidney injury (AKI) were septic (46.4%), ischemic (19.5%), post-operation (9.1%), and nephrotoxic (6.2%) AKI. Level of pH (hazard ratio (HR) 1.403, 95% confidence interval (CI) 1.181–4.774, 7.20 < pH ≤ 7.25; OR 3.520, 95% CI 1.330–9.316, 7.15 < pH ≤ 7.20; HR 4.315, 95% CI 1.649–11.286, pH ≤ 7.15; P-for-trend 0.001, reference pH > 7.3), weight gain over 2 kg (HR 2.501, 95% CI 1.552–4.032), urine output (HR 2.190, 95% CI 1.408–3.406, urine output ≤ 0.3 ml/min/kg), and phosphorus level (HR 2.136, 95% CI 1.199–3.805, 5.5 < P ≤ 6.5; HR 4.737, 95% CI 2.613–8.590; P-for-trend < 0.001, reference P < 5.5). However, serum creatinine level (HR 0.892, 95% CI 0.824–0.966)
and increased amount of serum creatinine level (HR 1.083, 95% CI 0.930–1.260) were not associated with in-hospital mortality. Diagnostic values of composite of these factors (pH, weight gain, urine output, and phosphorus levels) (area under find more the curve (AUC) 0.7145, 95% CI 0.656–0.771) was higher than serum creatinine level (AUC 0.449, 95% CI 0.382–0.517), GFR (AUC 0.553, 95% CI 0.485–0.62), and AKIN stage (AUC 0.589, 95% CI 0.521–0.657). Conclusion: These data may suggest that classical indication should be considered for the optimal timing for initiation of CRRT in critically ill patients. HATTORI YUKA1, KIM HANGSOO2, TSUBOI NAOTAKE2, YAMAMOTO AKIHITO1, UEDA MINORU1, MATSUO SEIICHI2, MARUYAMA SHOICHI2 1Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine; 2Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine Introduction: Acute kidney injury (AKI) is a critical condition which is
associated with high mortality rates of 30 to 50%. Ischemia-reperfusion injury (IRI) is a major cause of AKI. However, available treatments for AKI are limited. Preclinical studies indicate that administered MSCs ameliorate Farnesyltransferase renal injury and accelerate kidney repair. Recently, stem cells from human exfoliated deciduous teeth (SHED), which are medical waste, have received attention as a novel stem cell source. The purpose of this study is to clarify whether SHED have therapeutic effect on AKI induced by IRI. Methods: SHED were isolated from human exfoliated deciduous teeth as described previously. For all experiments 7- 8-wk-old male C57BL/6 mice weighing 18–22 g were used. Under anesthesia mice were subjected to right heminephrectomy.