The one-compartment model needs a correction of AUC by some formulas. In addition, no consensus on two formulas for correction of missing AUC is obtained. Extracorporeal GFR measurement using a gamma-camera is generally
inaccurate. Therefore, the equation might be different according to the method of reference GFR measurement. The direct comparison of renal and plasma clearance is necessary to evaluate the gap. The comparison of GFR measurement procedures is summarized in Table 3. In Table 4, methods for reference GFR measurement in different GFR equations are listed. Recently, the Japanese Society of Nephrology (JSN) has completed a project to create an eGFR equation fit for Japanese subjects.9 Inulin clearance was Selleckchem Fulvestrant performed in 763 patients with CKD under the protocol approved by the National Health Insurance Program (Fig. 1). All samples were measured in a single centre, and sCr values are IDMS-traceable. Japanese eGFR equations were created from the first dataset (n = 413), and those were validated by the second dataset (n = 350). Equations and their performance are shown in Table 5. The results show that a new Japanese equation has better performance to
estimate GFR than other equations when three variables (sCr, age and sex) are used. In addition, the BEZ235 solubility dmso estimated creatinine clearance (CCr) by Cockcroft–Gault equation can be converted to GFR for IDMS aligned creatinine assays by providing a Japanese coefficient of 0.789.9 In order to explore the possibility to create a common eGFR equation for Asian people, ACOS-CG-FREE
project was started in 2007 under the combined effort of five institutions including Yonsei University (Professor Ho Yung Lee, Seoul, Korea), Kaohsiung Medical University (Professor Hung-Chun Chen, Kaohsiung, Taiwan), Juntendo University (Professor Yasuhiko Tomino, Tokyo, Japan), Osaka University (Professors Enyu Imai and Masaru Horio, Osaka, Japan) and Nagoya University (Professor Seiichi Matsuo and Yoshinari Yasuda, Nagoya, Japan). In this collaborative work, all the samples were sent to a single central laboratory in Japan in order to avoid measuring bias. The same sets of samples are kept in each institution for the analysis. By the time of the Asian Forum of Chronic Kidney Disease Initiative 2009 (AFCKDI-2009) in Kaohsiung, Anidulafungin (LY303366) data from 96 Taiwanese subjects were analyzed and these data were used for external validation of the Japanese eGFR equation. The Japanese equation accurately estimated Taiwanese GFR from their serum creatinine with 74% within ±30% of the reference value. It is remarkable that performance of the new Japanese equation in Taiwanese is comparable to that in Japanese. This preliminary result suggests the possibility of creation of a common eGFR equation for Asians but further study is needed with increasing number of Taiwanese participants. Additional data from Seoul and Kaohsiung will be obtained over time and such possibility will be more precisely evaluated.