That is, carrying the GA and AA genotypes may increase ovarian

cancer susceptibility by 1.64-fold (95% CI: 1.37-1.95; P = 0.004) and 1.81-fold (95% CI: 1.56-2.14; P = 0.004) compared with the GG genotype respectively. The data in Table 2 indicated that no associations of p63 rs873330 T > C and p73 rs4648551 G > A with ovarian cancer pathogenesis were found. JNK-IN-8 research buy In summary, we determined that the rs6695978 A allele may be the at-risk allele for ovarian cancer, suggesting that carriers of the A allele may be more susceptible to ovarian cancer among Chinese women. Table 2 Logistic regression analyses on associations between p63 rs873330, p73 rs4648551, rs6695978 and risk of ovarian cancer Gene and SNP Genotype of SNP No. of subjects (%) Adjusteda Controls Cases P OR (95 % CI) p63 rs873330 T > C TT 182 (56.7) 160 (52.0) 0.142 1.00 (ref) TC 118 (36.8) 122 (39.6)   1.15 (0.88-1.52) CC 21 (6.5) 26 (8.4) 1.21 (0.78-1.89) T allele 482 (75.1) 442 (71.8) Milciclib   C allele 160 (24.9) 174 (28.2) 0.098 1.16 (0.79-1.68) p73 rs4648551 G > A GG 316 (97.5) 296 (96.1) 0.936 1.00 (ref) GA 8 (2.5) 10 (3.3)   1.05 (0.91-1.22) AA 0 (0.0) 2 (0.6)   G allele 640 (98.8) 602 (97.7)   A allele 8 (1.2) 14 (2.3) 0.558 1.41 (0.99-1.93) rs6695978 G > A GG 240 (74.1) 198 (64.3) 0.004 1.00 (ref)   GA 73 (22.5) 94 (30.5)   1.64 (1.37-1.95)   AA 11 (3.4) 16 (5.2) 1.81 (1.56-2.14)   G allele 553 (85.3) 490 (79.5)     A allele 95 (14.7)

126 (20.5) 0.003 1.55 (1.07-2.19) a. OR and 95% CI represent odds ratios and 95% confidence intervals from logistic regression analysis, adjusted for age, BMI, number liveborn, oral contraceptive use, cigarette smoking, ovarian

cancer family history. All statistical tests were two-sided with a significance level of P ≤ 0.05. The p73 rs6695978 G > A SNP was positively associated with known clinicopathological variables. Considering that none of the investigated SNPs except the p73 rs6695978 G > A had shown an association between the case group and the control group, we merely listed the data between the rs6695978 G > A genotype frequencies and the clinicopathological characteristics, including age at diagnosis, tumor histology, degree of differentiation, Liothyronine Sodium clinical stage , tumor behavior, lymph node status, estrogen receptor (ER) and progesterone receptor (PR) status (Table 3). The results from the logistic regression models revealed that the A allele was positively associated with the occurrence of mucinous ovarian cancer (OR = 3.48; 95% CI:1.15-6.83; P = 0.001), low degree of differentiation (OR = 1.87; 95% CI:1.03-3.47; P = 0.003), lymph node metastasis (OR = 1.69; 95% CI: 1.14-2.75; P = 0.010) and ER positive (OR = 2.72; 95% CI: 1.38-4.81; P = 0.002), which can be used to predict disease Vactosertib nmr prognosis and treatment outcomes. However, our analysis did not show significant associations of the polymorphism with age at diagnosis, clinical stage, tumor behavior and PR status.