role in the interaction, for higher drug concentrations the process is hydrophobically driven. Another finding was the decrease in Kp as drug concentration increases. That can be observed with the two techniques used and attributed to a saturation effect of themembrane, which is achievedwhen Gemcitabine Cancer the lipid/drug ratio is around 30. Gallois et al. determined the Kp for daunorubicin using negatively charged liposomes and found a value of 1,900 540, which is higher than the values obtained in our study, probably due to some degree of electrostatic interaction as the positive drug can be attracted to the negative lipid. These authors also concluded that daunorubicin interaction does not depend on the drug,s or liposome,s charge, and in another study Gallois et al. detected only hydrophobic interactions by this molecule.
These findings are probably due to the techniques used or the drug concentration used. Conclusions This article describes the GSK690693 937174-76-0 interaction of daunorubicin with the membrane of EPC liposomes. In the interaction of daunorubicin with the membrane, both electrostatic and hydrophobic forces seem necessary for the stabilization of anthracyclines in the lipid bilayer. The determination of Kp by derivative spectrophotometry is based on the spectral changes occurring when drug and membrane interact and thus must reflect mostly the hydrophobic interaction. On the other hand, zeta potential variations reflect a charge increase, caused by the partition of a charged molecule in the lipid bilayer.
Our results show that for lower drug concentrations the electrostatic Etoposide attraction to the membrane strongly accounts for the global partition coefficient, while for higher drug concentrations the hydrophobic interpenetration is the main single driven force for the interaction. Another finding was the saturable nature of daunorubicin interaction within the membrane. In fact, a minimum of 30 lipid molecules seems to be necessary to dissolve each drug molecule in the bilayer environment. non toxicity, biocompatibility and biodegradation.38,39 CTS is particularly attractive with regard to the presence of abundant amino groups.40 Furthermore, CTS, which could form a NH2 metal drug coordination bonding architecture on the mesopores, can be utilized as a good candidate for the host part in this pH responsive delivery system.
Zinc has been utilized for coordination combining host and guest molecules due being nontoxic, biocompatible and metabolizable in the organism. DNR with coordination bonding capable amino and hydroxyl groups have been chosen as a model guest molecule. A biodegradable mesoporous CTS silica hybrid has been synthesized by self assembly of F127, and a biodegradable CTS and silica source through a real liquid crystal templating route. CTS in framework of CTS silica hybrids can be degraded to small molecules by enzyme in the body of animals, which would make these CTS silica hybrids biodegradable.41 A NH2 Zn DNR coordination bonding architecture has been constructed, accompanied by the formation of CTS silica mesostructured hybrid. This NH2 Zn DNR coordination bonding system is stable under physiological pH conditions and readily releases the encapsulated drugs in response to a reduction in pH due to breakdown of both or either the NH2 Zn and Zn DNR