However, therapeutically relevant hyperthermia (>40°C was achieve

However, therapeutically relevant hyperthermia (>40°C was achieved within 10 min following 4SC-202 mw exposure to an alternative magnetic field between 7 and

17 mT. These results underline that biocompatible, phospholipid-coated SPIONs offer exciting opportunities as thermoresponsive drug delivery carriers for targeted, stimulus-induced therapeutic interventions. Acknowledgements The authors would like to thank Richard (Jason) Sookoor (University of Cincinnati, Department of Physics) for his assistance with the SPION synthesis. This research was supported in part by a predoctoral fellowship selleck chemicals llc from the Egyptian Ministry of Higher Education awarded to Ayat A. Allam. References 1. Liu J, Jiang Z, Zhang S, Saltzman WM: Poly(omega-pentadecalactone-co-butylene-co-succinate) nanoparticles as biodegradable carriers for camptothecin delivery. Biomaterials 2009, 30:5707–5719.CrossRef 2. Tung WL, Hu SH, Liu DM: Synthesis of nanocarriers with remote magnetic drug release control and enhanced drug delivery for intracellular

Salubrinal manufacturer targeting of cancer cells. Acta Biomater 2011, 7:2873–2882.CrossRef 3. Andhariya N, Chudasama B, Mehta RV, Upadhyay RV: Biodegradable thermoresponsive polymeric magnetic nanoparticles: a new drug delivery platform for doxorubicin. J Nanoparticle Res 2011, 13:1677–1688.CrossRef 4. Gupta AK, Gupta M: Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 2005, 26:3995–4021.CrossRef 5. Di Marco M, Guilbert I, Port M, Robic C, Couvreur P, Dubernet C: Colloidal stability of ultrasmall superparamagnetic iron oxide (USPIO) particles with different coatings. Int J Pharm 2007, 331:197–203.CrossRef 6. Gupta AK, Wells S: Surface-modified superparamagnetic nanoparticles for drug delivery: preparation, characterization, and cytotoxicity studies. IEEE Trans Nanobioscience 2004, 3:66–73.CrossRef to 7. Kim DW, Kim TH, Choi S, Kim KS, Park DW: Preparation of silica coated iron oxide nanoparticles using non-transferred arc plasma. Adv Powder Tech 2012, 23:701–707.CrossRef 8. Goodarzi A, Sahoo Y, Swihart MT, Prasad BN: Aqueous ferrofluid

of citric acid coated magnetite particles. Mater Res Soc 2004, 789:61–66. 9. Yeap SP, Ahmad AL, Ooi BS, Lim J: Electrosteric stabilization and its role in cooperative magnetophoresis of colloidal magnetic nanoparticles. Langmuir 2012, 28:14878–14891.CrossRef 10. Mandel K, Hutter F, Gellermann C, Sextl G: Synthesis and stabilisation of superparamagnetic iron oxide nanoparticle dispersions. Coll Surf A 2011, 390:173–178.CrossRef 11. Nikiforov VN: Magnetic induction hyperthermia. Russian Phys J 2007, 50:913–924.CrossRef 12. Huth C, Shi D, Wang F, Carrahar D, Lian J, Lu F, Zhang J, Pauletti GM: Phospholipid assembly on superparamagnetic nanoparticles for thermoresponsive drug delivery applications. Nano LIFE 2010, 1:251–261.CrossRef 13.

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