” At the time of his appointment there had been no sustained acad

” At the time of his appointment there had been no sustained academic interest in liver disorders in children in the United Kingdom. Under Alex’s influence, hard work, dedication, and organizational ability the KCH became a first-class clinical service for children with liver disease combined with a productive research unit. His vision also led to the recruitment of parents of children on the Liver Service to develop what has become the Children’s Liver Disease Foundation. Alex Mowat developed a close partnership with Professor Ted Howard, a pediatric surgeon, thereby integrating compound screening assay medical and surgical care of children with liver disease into this unique unit. Giorgina Mieli-Vergani


as the unit grew to become a supraregional center in the UK for the treatment of hepatobiliary disease in children. Alex Mowat’s experience at KCH was compiled into his textbook Liver Disorders in Childhood, first published in 1979, which carefully cataloged and characterized the myriad patients cared for by his “team” at KCH from 1970 to 1976.[38] In his preface, Alex stated that his aim was to “summarize recent developments and indicate some of the outstanding clinical problems in areas in which research is urgently needed.” His plea motivated me and others to take up the challenge, stimulating focused investigation in this discipline. This may have been the first time that we had the distinct sense that a new area of subspecialization was developing. Mowat’s vision therefore predated the flurry Selleckchem Ganetespib of activity in Pediatric Hepatology attendant to the development of centers of excellence in Pediatric Hepatology around the world. A major seminal event in the maturation of the discipline, and in my personal development, was a meeting

held in 1977 that focused on the codification and delimitation of MCE公司 the field of interest of Pediatric Hepatology. An international workshop, sponsored by the National Institutes of Arthritis, Metabolism, and Digestive Diseases (NIAMDD), was convened by Norm Javitt.[39] This conference gathered together individuals such as Morio Kasai, Alex Mowat, Daniel Alagille, Birgitta Strandvik, and Andrew Sass-Kortsak, among others. As stated by G. Donald Whedon (NIAMDD) “…one of the goals of this conference is to develop a uniform nomenclature with specific criteria for diagnosis. With the convergence of expertise from virologists, microbiologists, epidemiologists, embryologists, immunologists, neonatologists, hepatologists, pediatric gastroenterologists, pathologists, and surgeons, we are going to either make great strides forward or build a new tower of Babel … as a spinoff of this conference, there may be a continuing effort to plan cooperative clinical trials or to set up a registry of cases and a repository of sera or tissues.

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