Alkalinizing agents including sodium bicarbonate
(NaHCO3) have been proposed as ergogenic aids for their potential effects on providing enhanced extracellular buffer capacity, leading to the elevated proton (H+) efflux from the contracting musculature [9, 10]. The increased intramuscular [H+] during exercise has been considered as one of the major causes of muscle fatigue . It has been suggested that H+ accumulation would inhibit the enzymes involved in oxidative phosphorylation and glycolysis. It would also reduce Ca2+ binding to troponin C and inhibit the sarcoplasmic reticulum enzyme Ca2+-ATPase [11, 12]. Indeed, previous studies generally agreed that NaHCO3 supplementation was beneficial for the performance in a single bout of high-intensity exercise lasting 1-7 min [13, 14], and intermittent short-term high-intensity exercise [15–17]. It has mTOR inhibitor also been shown that NaHCO3 supplementation increased the total work output during a 1-hr competitive cycling . Furthermore, NaHCO3 supplementation could improve total power output in a 30 min high-intensity intermittent
cycling exercise representative MLN8237 datasheet of various ball games . Nevertheless, several studies failed to find ergogenic effect of NaHCO3 supplementation on exhaustive short-term cycling  or resistance exercise . Recently, the potential role of NaHCO3 supplementation in alleviating the exercise-induced impairment Thymidylate synthase in the neural functions has been proposed. NaHCO3 supplementation has been shown to increase muscle fiber conduction velocity and reduce force decline in sustained maximal contraction after a 50-min submaximal cycling . With the potential role of NaHCO3 in preserving the neural functions after prolonged exercise, we hypothesized that NaHCO3 supplementation may prevent the fatigue-induced decline in skilled tennis performance. The aim of
this study was to investigate the effect of NaHCO3 supplementation on skilled tennis performance after a simulated match. Materials and methods Participants Nine male Division I buy YH25448 College tennis players (age 21.8 ± 2.4 years; height 1.73 ± 0.07 m) were recruited. All participants have competed in the national level. All participants were given their written informed consent. The study protocol was approved by the Human Subject Committee of National Taiwan College of Physical Education. Experimental design This study used a randomized cross-over, placebo-controlled, double-blind design. Each participant completed 2 experimental trials, bicarbonate and placebo, in a randomized order. The 2 trials were separated by 1 week. The schedule of dietary supplementation, exercise test, and blood sampling is shown in Figure 1. All trials were performed in the same outdoor tennis court with a hard surface. The temperature at the start of the exercise was 34.5 ± 3.2°C and 34.4 ± 3.4°C in the placebo and bicarbonate trial, respectively. The relative humidity was 47.