There, erectile dysfunction, fatigue, Hepatotoxizit t, h Dermatological toxicity of t, the hypothyro The, and ocular toxicity T. F ll Of exacerbation of psoriasis and induce de novo psoriasis and psoriatic arthritis have been reported.78 interferon application may need during the pregnancy has not been formally studied, it has been administered, however, to rhesus monkeys at Adrenergic Receptors doses similar to those in humans administered and has abortifacient effects 0.79 5-fluorouracil reduced current 5-FU cell proliferation and cell death, especially in cells with high mitotic rate, through inhibition of thymidylate synthetase with DNA synthesis.80 st rt, schl gt 81 demonstrate that 5-FU was used as a topical chemotherapeutic agent NMSC was keratoses in the treatment of surface- chlichen BCC, SCC in situ, and actinic.
Not due to lack of penetration into the dermis, 5-FU is generally recommended for BCC and invasive SCCs.5, 81 Several studies compared the effectiveness of topical ointment 5% 5-FU for the treatment of NMSC reported, with most patients rating their excellent cosmetic outcome as good to excellent. However, high recurrence rates h Frequently reported.82, 83.85 A total of Valproate 103 patients with invasive basal cell carcinoma have been with 5-FU at concentrations of 1 to 5% t twice Resembled treated for a range of 1 to 5 weeks already. Although 25 percent of the F Lle had treated the bottle Surface normal-appearing skin, and the remaining F Lle were small ulcerated neoplastic tissue showed all F Ll microscopic evidence of invasion histologically controlled after excision It.
5-FU-controlled The superficially Chliche part of the BCC, resulting in a relatively benign clinical tumors, which have to delay Delays in definitive treatment for up to 18 months.84 Several studies compared the efficacy, safety and cosmetic results of 5-FU and photodynamic therapy for the treatment of Bowen’s disease and organ transplantation in both immunocompetent86 patients.86 88 In both groups of patients, PAH showed superior efficacy, fewer recurrences and that less may need during the treatment and after 12 months of follow up.87, 88 In addition, PAHs have been better cosmetic results than 5-FU achieved. Hamouda and AL88 treated 10 patients with inoperable SCC several XP patients with 5-FU twice t Possible for an average of six months.
Although the clinical regression surface Che in most patients have been reported, showed after treatment biopsies in five patients clearance of epidermal ulceration in a patient and persistent deep dermal components in the remaining four samples. A total of 14 Older patients with biopsy-proven SCC aggressive, multiple or recurrent, it was vers umt, The standard therapies were oral 5-FU 175mg/m2 three weeks long t Was like every five years weeks.89 oral 5-FU treated effective and well tolerated possible, although further studies are needed to evaluate its true clinical value. With regard to the topical treatment of actinic keratoses, 5-FU has demonstrated its efficacy rates90 94 However, recurrence is h Frequently a consensus of 95 and less due to adverse events were reported in 60 percent of the combined treatment of topical 5-FU failures.96 The advantage of the treatment is not clinically detectable AKs.93 The combination of 5-FU and imiquimod is currently in a row faster reactions and less AEs.97 studies investigating the r of 5-FU in the diff