In fact, the cellular pathways of DNA repair more involved in the response to radiation injury are DSBR and BER In vitro and in vivo studies have shown that polymorphisms of genes involved in these two mechanisms of DNA repair may influence the cellular sensitivity to RT [48–50]. Our results showed no significant association between XRCC3 C18067T and radio-sensitivity in agreement with studies by Andreassen et al. and Chang-Claude et al. [51–53] in breast cancer patients or by Alsbeish et al. in head and neck cancer patients . An association between wild type XRCC3 C18067 and an increased rate of late toxic effects, such as subcutaneous
fibrosis, were found in breast cancer  and prostate . No statistical significant association between XRCC1 Arg399Gln and radio-sensitivity was found in our study, as well as in other studies [17, 19, 57]. However, Forest Epigenetics Compound Library research buy plot showed a behaviour as toxic agent of mut/het XRCC1 Arg399Gln in agreement with an increased rate of lung effects in non small cell lung cancer patients. . Finally, no correlation was found between late toxicity mut/het XRCC3 A4541G and mut/het RAD51. Our low correlation between incidence of G2 or more fibrosis or fat necrosis and alleles/patient is probably due to the low number of patients with G2 or more fibrosis or fat necrosis. Another issue to consider is
that in comparison of other findings some differences are www.selleckchem.com/products/poziotinib-hm781-36b.html expected due to the types of adverse reactions studied, the length of follow-up for observing side effects, as well as, the additional patient-related factors. Conclusions The presence of some SNPs involved in DNA repair or response to oxidative stress seem to be able to predict late toxicity. This study, although affected by a limited number of patients, has a power of the study statistically L-NAME HCl sufficient to suggest that SNP in GSTP1 gene could
be useful to predict late toxicity in BC patients who underwent SSPBI. Further data are needed to confirm these preliminary results. Moreover, future research will focus on the performance of many additional SNPs in other genes that are associated with the development of radiation toxicity. Acknowledgements The Authors wish to thank Mrs. Tania Merlino for the English revision References 1. Veronesi U, Marubini E, Mariani L, Galimberti V, Luini A, Veronesi P, Salvadori B, Zucali R: Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial. Ann Oncol 2001, 12:997–1003.PubMedCrossRef 2. Fisher ER, Anderson S, Redmond C, Fisher B: Ipsilateral breast tumor recurrence and survival following lumpectomy and irradiation: pathological findings from NSABP protocol B-06. Semin Surg Oncol 1992, 8:161–166.PubMed 3. Veronesi U, Luini A, Del Vecchio M, Greco M, Galimberti V, Merson M, Rilke F, Sacchini V, Saccozzi R, Savio T, et al.: Radiotherapy after breast-preserving surgery in women with localized cancer of the breast.