Temsirolimus and a third had mucosal oedema. Twenty-seven percent of patients had crusti and a third had a deviated septum. Six percent had nasal polyps. Eight out of 8 subjects had normal CT scans of their nose and sinus had mucosal thickening in at least sinus and had at least one opacid sinus. All patients reported taking their three topical treat-ments regularly and none reported any adverse events. At the end of the treatment peri ve out of 8 patients reported a signi ant improvement in their cough symp-toms. Two of the three patients without clinical evidence of PND at the time of examination reported an improvement in their cough after the treatment period. There was a signi ant decrease in mean cough severity score post-treatment but no signi ant change in LCQ score overall .
There were no signi ant changes in exhaled nitric oxi lung function or capsaicin cough Alvespimycin sensitivity post-treatment . There was also no signi ant change in nasal catarrh questionnaire scores and in PND symptom scores . Howev there was a signi ant clinical improvement in anterior nasal discharge symptom score apanied by a signi ant improvement in endoscopic nasal scores post-treatmen charac-terised by reduction in discharge and oedema. There was a signi ant correlation between baseline LCQ score and baseline mean cough score . There was no correlation between LCQ score and capsaicin or between change in cough severity score and change in anterior or posterior nasal discharge scores. Discussion In this pilot stu we examined the effect of topical treatments for rhinosinusitis on the symptoms of postnasal drip and apanying chronic cough in a cohort of patients with chronic cough as their main symptom. The treatments used were topical corticosteroi and nasal applications of -antihistamines and Bosutinib 380843-75-4 anticholinergic nasal spray.
No antibiotics or saline sprays were given. Overa treatment was associated with a signi ant improvement in cough scores post-treatment that apanied reductions in symptom scores for anterior nasal dischar NS Pre Post Pre Post Figure Self-administered cough score and nasal catarrh questionnaire scores before and after treatment of rhinosinusitis. Nasal catarrh score cough questionnaire score Postnasal drip and cough A Exhaled nitric oxide B 5 Lung function Pre Post 0 Pre Post C Leicester Cough Questionnaire D buy AZD2171 Capsaicin cough sensitivity Pre Post Pre Post Figure Individual values for exhaled nitric oxid lung function as FEV predicte Leicester cough questionnaire score and capsaicin cough sensitivity as log before and after treatment of rhi-nosinusitis. None of the parameters shows signi ant changes. signi ant reduction for postnasal dischar and no changes in the nasal catarrh questionnai although direct inspection of the nasal passages showed improvement in the appearances of the nasal mucosa.
We observed no signi ant changes in capsaicin cough sensitivity or the Leicester Cough questionnaire. Our data suggest that treating PND syndrome with abination of topical soul corticosteroi antihistamines and anticholinergic lead to a modest improvement in chronic cough although this requires conmation in a randomised controlled study. At the end of our stu 8 of patients had reported an overall improvement in their cough scores following treatment.