So investigation of proteine kinase inhibitor pyrrol derivative 5

So investigation of proteine kinase inhibitor pyrrol derivative 5-amyno-4-(1,3-benzothyazol-2-yl)-1-(3-methoxyphenyl)-1,2-dihydro-3Н-pyrrol-3-one (D1) effects on intestine mucosa proliferation in normal and experienced colon cancer rats compared with a common therapeutic 5-fluorouracil (5-FU) ones was aimed. Methods: 1,2-Dimethylhydrazine (DMH)-induced rat colon cancer model was used. Mitotic index (MI) in jejunum, colon and rectum mucosa epithelial cells and crypt fission index (CFI) in colon and rectum mucosa, tumor number (Ntumor), tumor mean and total area (Stumor, Stotal) per animal were counted;

correlation analysis was conducted. Results: Colon MI decrease by 27%, 37% and 46% was observed in groups II, VI, VIII respectively. Jejunum MI decrease by 31% in VII, colon MI decrease by 41% BMN 673 and 42% in III and VII respectively compared with I was observed. Ntumor decrease by 41%, 50%, 46% in V, VII and IX

respectively, and Stotal decrease by 41% and 46%, 43%, 54% in III, V, VII and IX respectively, were revealed. Correlation coefficients between Ntumor and Stotal and colon mucosa МI and CFI were computed. Direct relation to Ntumor of МI and CFI, direct relation to Stotal of MI and inverse relation to Stotal of CFI were demonstrated, indicating the relative independence of crypt fission of cell proliferation and their different roles in tumor initiation and growth processes. Conclusion: Lower inhibition of gut mucosa cells proliferation caused this website by D1 in comparison

to 5FU and their similar antitumor effects were concluded. Key Word(s): 1. colon cancer; 2. mucosa proliferation; 3. pyrrol derivative; 4. 5-fluorouracil; Presenting Author: JING JIANG Additional Authors: XUEYUAN CAO, FEI KONG, ZHIFANG JIA, DONGHUI CAO, MEI-SHAN JIN Corresponding Author: JING JIANG Affiliations: First Hospital of Jilin University Objective: Both CD44 and CD24 are known to contribute to cellular signaling and cell adhesion, and considered as are cancer stem cell markers. The aim of this study is to explore the alteration of CD44 and CD24 expression in gastric cancer selleckchem and to assess its prognostic values. Methods: Two hundred and ninety consecutive cases of gastric cancer were enrolled in the study. CD24 and CD44 expression was carried out in 290 gastric cancer specimens, of which 77 had paired adjacent normal gastric mucus samples by performing a tissue microarray immunohistochemistry method. Correlations were analyzed between expression levels of CD24 and CD44 protein and tumor parameters or clinical outcomes. Serum anti-Helicobacter pylori (H.pylori) IgG were detected by enzyme-linked immunosorbent assay method.

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