Sequences with sharp components are mixed, with minimal diffusion of the contralateral homologous regions. Clinically, the patient shows the same features of the above described matter of what lle. Such a T ACTION gradually down, and after 2 minutes, follow the patient in a position to simple commands, although eyes Opening not significantly Change the focal EEG discharges. This critical activity T allm Hlich off and stopped within 6 minutes. Oxcarbazepine dose was therefore increased to 900 mg ht / day. Another standard EEG recording and sleep ridiculed Ngerte video / EEG recording were normal. The results of MRI of the brain were normal. Two months later Ter under Rztlicher supervision, sheDetoxification for BDZ abuse recently developed a method in patients with chronic dependence BDZ dependence is performed and generally safe, few complaints k Rperlicher mental or abstinence. In the literature, most of the information on the occurrence of cases reqs After abrupt discontinuation BDZ, w While previously the need during the drug Sen treatment were confiscated because of misuse of benzodiazepines not been systematically studied and evaluated. More than 7 years went on, our group of detoxification with flumazenil 286 patients with generalized Krampfanf Lle, which occur in eight of them PI3K AKT Signaling Pathways described, and focal reqs Ll nonconvulsive in 2 patients here. A Similar observation was made previously in a study to evaluate the proportion of drug seizures reported retrospectively 279 patients. Our patients had nonconvulsive reqs Lle to announce where clinical and EEG features Have a focus on involvement of the cerebral cortex, without evidence of intracerebral L emissions. Neither patient was forfeited to the alcohol or taking drugs that lower the seizure threshold, or the patient had a history of Hirnsch Or the beginner Lle, and MRI were normal.
So there was no other reason, au He stopped BDZ, for beginner Ll of these patients. In humans, the effects of flumazenil on Anfallsaktivit t are controversial. Although induction and exacerbation of reqs Lle reported in some studies, the suppression of interictal discharges and a reduction of Anfallsh FREQUENCY with flumazenil treatment have been reported in other studies. However, in the case of beginner Ll k can With the administration of flumazenil search terms, seems to be a pre-treatment of patients with CHF to proconvulsive be a prerequisite for the effect of this drug. Although a latent seizure disorders through a Aminopeptidase pl USEFUL interruption of benzodiazepines can be unmasked k, We consider our patients with acute situational crisis related to the setting BDZ, which did not enter by yourself Not a diagnosis of epilepsy. The fact that our patient developed focal rather than generalized fill reqs Is surprising. Benzodiazepines are drugs that act on GABA receptors diffuse st strengths Ant and GABAergic neurotransmission, so that after deduction of BDZ, a rebound generalized epileptogenicity and cortical excitability involving the entire cortex, not only a circumscribed cortical area can be expected. Counter-regulation of GABAergic neurotransmission enhanced by improving the glutamatergic neurotransmission is believed to be one of the reasons behind the symptom My typical BDZ withdrawal. The existence of different levels of health epileptogenicity in different brain regions of the.
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