Montgomery Bissell for critical reading of the article. Additional Supporting Information may be found in the online version of this article. Selleckchem Crizotinib “
“Non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, is associated with an increased risk of developing lifestyle-related diseases including type 2 diabetes, cardiovascular disease and cerebral vessel disease. No current drug therapy
provides the ideal effects of decreasing hepatic inflammation while simultaneously improving liver fibrosis. Liraglutide is a glucagon-like peptide-1 receptor agonist that affects the histological findings in patients with non-alcoholic steatohepatitis (NASH). This study was conducted to evaluate the effect and action of liraglutide for biopsy-proven NASH. After lifestyle modification intervention for 24 weeks, subjects whose hemoglobin A1c levels failed to improve to less than 6.0% and/or whose alanine aminotransferase levels were not lower than baseline, received liraglutide at 0.9 mg/body per day for 24 weeks.
Of 27 subjects, 26 completed the lifestyle modification intervention. Nineteen subjects received liraglutide therapy for 24 weeks. Body mass index, visceral fat accumulation, aminotransferases and glucose abnormalities improved significantly. Repeated liver biopsy was performed in 10 subjects who continued liraglutide therapy for 96 weeks. Selleckchem Paclitaxel Six subjects showed decreased histological inflammation as determined by NASH activity score and stage determined by Brunt
classification. We saw no significant adverse events during therapy with liraglutide. Our pilot study click here demonstrated that treatment with liraglutide had a good safety profile and significantly improved liver function and histological features in NASH patients with glucose intolerance. “
“Dysphagia is an alarm symptom and requires further investigation. Dysphagia is typically categorized as oropharyngeal or esophageal. Patients with oropharyngeal dysphagia should have video fluorscopic swallowing studies and evaluation by a swallowing rehabilitation expert. Patients with esophageal dysphagia require endoscopy. Patients with endoscopy negative esophageal dysphagia should have esophageal biopsies to evaluate for eosinophilic esophagitis; if negative they should have esophageal manometry. Treatment for all types of dysphagia is targeted at the underlying cause. “
“Background and Aims: Plasmodium falciparum (PF) infection can lead to severe complications. Ursodeoxycholic acid (UDCA) is increasingly used for the treatment of cholestatic liver diseases. The present study aims to determine the effects of combined UDCA and artesunate compared to placebo and artesunate on the improvement of liver tests in severe PF jaundiced patients. Methods: All severe PF jaundiced patients, aged ≥ 15 years and diagnosed as having severe malaria according to WHO 2000 criteria, were enrolled.