However, both LEA and HEA increased the level of S-SCF in 8 weeks compared with DM group. Conclusion: LEA and HEA at ST36 promoted the contraction of gastric antrum involved the SCF/c-kit pathway in diabetic rats. Key Word(s): 1. EA; 2. ICC; 3. contraction; 4. SCF/c-kit pathway; Presenting Author: KUILIANG LIU Additional Authors: JING WU, XIANGCHUN LIN, GUOJUN JIANG, HUI SU, HUI GE Corresponding Author: JING WU Affiliations: Beijing Shijitan Hospital Objective: To determine the high-resolution manometry (HRM) characteristics of esophageal motion in GERD patients which remains unknown. Methods: Analyze retrospectively the clinical data
buy Buparlisib of patients underwent HRM using Manoscan™ (Given Imaging, Los Angeles, CA) between Nov. 2011 PI3K Inhibitor Library and Apr. 2013 in our institution. Identify the GERD patients without gastrointestinal neoplasm or surgery. Results: A total of 95 patients, including 36 males and 59 females, were included, the average age was 56.3 ± 11.8 years old. The average LES resting pressure was 13.37 ± 6.52 mmHg, LES residual pressure was 8.89 ± 4.94 mmHg, contractile front velocity (CFV) 4.13 ± 2.01 cm/s, intra bolus pressure (IBP) 3.90 ± 3.30 mmHg, distal Latency (DL) 6.50 ± 1.63 s, distal contraction integral
(DCI) was 1365.80 ± 1296.68 mmHg-s-cm. Compared to patients with DCI over 450 mmHg-s-cm, 23 patients (24.2%) with DCI no more than 450 had more extraesophageal symptoms (43.5% vs 21.0%, p = 0.013) and esophageal mucosa damage (47.8% vs 40.3%, p > 0.05). FER According to Chicago criteria of 2012,
in 948 evaluable swallows, 101 (10.7%) were failed peristalsis, 15 (1.5%) were weak contraction with large break, 94 (9.9%) were weak contraction with small break, 11 were panesophageal pressurization, 35 (3.7%) were premature contraction, 22 were rapid contraction (2.3%),1 was hypercontractile. Besides, 9 patients (9.5%) had motility disorder, including 2 of absent peristalsis, 6 of distal esophageal spasm, 1 of hypercontractile esophagus; 24 patients (25.3%) had peristaltic abnormalities, including 7 of frequent failed peristalsis, 2 of weak peristalsis with large breaks, 13 of weak peristalsis with small breaks (1 had accompanied rapid contraction); 3 of rapid contractions with normal latency; 6 patients (6.3%) had EGJ outflow obstruction. In patients with distal esophageal spasm, 2 (33.3%) had additional retrosternal pain and mild dysphagia respectively; in patients with rapid contractions with normal latency, 1 (33.3%) had additional mild dysphagia; in patients with EGJ outflow obstruction, 2 (33.3%) had additional retrosternal pain and mild dysphagia respectively. Conclusion: Decreased esophageal peristalsis is common in GERD patients and might be associated with extraesophageal symptoms; the significance of occasionally enhanced motion as well as IBP remains to be explored. Key Word(s): 1. esophageal motion; 2. GERD; 3.