3 vs 54±12.1, p=0.003) and had lower Hb levels (9.3±2.3 vs 10.8±2.2g/dL, p=0.01) compared to NVB. VB was more frequent in women than in men (65% vs 34%, OR 3.6, 95% CI1.24–10.5, p=0.02) There were no significant differences in etiology and severity of cirrhosis, type and extent of PVT in VB and NVB patients. Patients with VB were less likely to receive anticoagulant therapy (OR 0.24 95%CI high throughput screening assay 0.069–0.84, p=0.03). A trend for lower PVR rates was observed in patients with VB at diagnosis of PVT compared to NVB (25% vs 50%, p=0,069) By Cox and logistic regression analysis, there were no differences
in mortality at end of FU (p=0.24) and at 1 year (p=0.42) between VB and NVB. Interestingly, mortality in patients with VB was lower at 3 years compared to NVB (0R 0.17, 95% CI 0.04–0.75, p=0.03). Kaplan Meier survival analysis showed that mortality in patients with VB at PVT diagnosis did not differ significantly from that in NVB or
controls without PVT. Conclusion: Variceal bleeding at diagnosis of PVT in patients with cirrhosis does not increase mortality and is significantly more frequent in older and female patients. Disclosures: selleck chemicals Carlos Noronha Ferreira – Advisory Committees or Review Panels: ABBVIE; Consulting: Bristol Myers Squibb Jose F. Velosa – Advisory Committees or Review Panels: Bristol Meyers Squibb, Gilead Sciencs; Consulting: Roche Pharmaceutics The following people have nothing to disclose: Teresa Rodrigues, Patricia Sousa, Fernando Ramalho, Paula Alexandrino Background and aims: Portal hypertension leads to major complications of cirrhosis. Until now the invasive measurement of hepatic venous pressure gradient (HVPG) is the only method used for exact evaluation of portal hypertension. Osteopontin is a new marker with possible relation to fibrosis, cirrhosis staging and hepatocelular carcinoma. The aim of our study was to evaluate the relationship of osteopontin serum concentrations to the severity of portal hypertension pheromone in patients with cirrhosis. Methods: 154 patients with liver cirrhosis (112 ethylic, 108 men, age 34-72 years) were enrolled. The diagnosis of liver cirrhosis was confirmed by liver biopsy. HVPG measurement, laboratory
and ultrasound examination were performed in all patients. HVPG was measured by standard catheterisation balloon wedged technique. Osteopontin was measured by standard ELISA technique. Control group consists of 59 healthy age- and sex-matched individuals. Results: The mean value of HVPG in cirrhotic patients was 16.18±5,6 mm Hg. The values of osteopontin in cirrhotic patients were significantly higher than values in controls (145±114 vs. 56.3±17.1 ng/ml; p< 0.001). The levels of osteopontin were closely positively related to the HVPG values (p=0.0022). Moreover the levels of oste-opontin above 80 ng/ml could discriminate the patients with significant portal hypertension (HVPG above 10 mm Hg) with 75% sensitivity and 60% specificity (AUC 0.